We developed BSP-SLIM, a new method for ligand-protein blind docking using low-resolution protein structures. For a given sequence, protein structures are first predicted by I-TASSER; putative ligand binding sites are transferred from holo-template structures which are analogous to the I-TASSER models; ligand-protein docking conformations are then constructed by shape and chemical match of liga...

The best arguments for the 1/3 answer to the Sleeping Beauty problem all require that when Beauty awakes on Monday she should be uncertain what day it is. I argue that this claim should be rejected, thereby clearing the way to accept the 1/2 solution. 1 Inertia and Sleeping Beauty If on Monday you confidently and rationally believe that Slippery Slim is guilty, and from Monday to Tuesday you ga...

With the current national emphasis on translational research, data-exchange systems that can bridge the basic and clinical sciences are vital. To meet this challenge, we have developed Slim-Prim, an integrated data system (IDS) for collecting, processing, archiving, and distributing basic and clinical research data. Slim-Prim is accessed via user-friendly Web-based applications, thus increasing...

زمینه و هدف: بیماری کبد چرب غیرالکلی رایج‌ترین کبدی است که در حال پیشرفت بوده بیش از یک‌چهارم مردم جهان را درگیر خود ساخته است. این پژوهشگران معتقدند فعالیت ورزشی استفاده داروهای گیاهی با خواص ضدچربی ضداکسایشی می‌تواند به‌عنوان درمان مکمل، سودمند باشد. بنابراین، هدف پژوهش تعیین آثار هشت هفته تمرین هوازی یا مصرف عرق آرتیشو بر سطوح چربی سرمی آنزیم‌های زنان مبتلا به بود. مواد روش‌ها: بدین‌منظور، 2...