نتایج جستجو برای: 142 kda
تعداد نتایج: 48649 فیلتر نتایج به سال:
هدف از این مطالعه بررسی اشک چشم افرادی است که در طی جنگ ایران و عراق با گاز خردل مواجه شده اند و دارای ضایعات چشمی با نشانه هایی از خشکی چشم مزمن هستند و با افراد سالم برای یافتن میزان فعالیت آنزیم های mmp-2 و mmp-9 مقایسه شده اند. روش کار: در این مطالعه 21 فرد از بین جانبازان شیمیایی که با گاز خردل مواجه شده اند و دارای خشکی چشم و ضایعات چشمی همچون بلفاریت هستند به عنوان گروه بیمار با 18 فرد...
MicroRNAs are differentially expressed in cells and regulate multiple biological processes. We have been analyzing comprehensive expression patterns of microRNA in human and mouse embryonic stem and induced pluripotent stem cells. We determined microRNAs specifically expressed in these pluripotent stem cells, and miR-142-3p is one of such microRNAs. miR-142-3p is expressed at higher levels in i...
Canonical Wnt signaling is critical for the control of osteoblast differentiation in human mesenchymal stem cells. MicroRNAs (miRs) are essential regulators of cell differentiation by post‑transcriptional regulation of target gene expression. The aim of the present study was to investigate the molecular mechanism by which miR‑142‑3p promotes osteoblastic differentiation using the human fetal os...
Neutrophils play critical roles in vertebrate innate immune responses. As an emerging regulator in normal myelopoiesis, the precise roles of microRNA in the development of neutrophils have yet to be clarified. Using zinc-finger nucleases, we have successfully generated heritable mutations in miR-142a and miR-142b and showed that hematopoietic-specific miR-142-3p is completely deleted in miR-142...
An increase in cardiac workload, ultimately resulting in hypertrophy, generates oxidative stress and therefore requires the activation of both survival and growth signal pathways. Here, we wanted to characterize the regulators, targets and mechanistic roles of miR-142, a microRNA (miRNA) negatively regulated during hypertrophy. We show that both miRNA-142-3p and -5p are repressed by serum-deriv...
Aberrant expression of microRNAs (miRs) has been implicated in the pathogenesis of several neurodegenerative disorders. In HIV-associated neurocognitive disorders (HAND), miR-142 was found to be upregulated in neurons and myeloid cells in the brain. We investigated the downstream effects of chronic miR-142 upregulation in neuronal cells by comparing gene expression in stable clones of the human...
Objective(s) Garlic (Allium sativum) is known as a potent spice and a medicine with broad therapeutic properties ranging from antibacterial to anticancer, and anticoagulant. One of the major purified garlic protein components is the 47 kDa protein. In this study, the effect of 47 kDa protein extracted from aged garlic (AGE) was evaluated on mouse dendritic cell (DC) maturation in vitro. Mate...
A size partitioning of several trace metals (Zn, Cd, Pb, Cu, Ni, Co, Mn, Fe and Al) between five fractions (<3 kDa, 3 kDa–0.1 µm, 0.1 µm–1.2 1.2 µm–5 µm >5 µm) was studied in the vertical salinity gradient highly stratified Krka River estuary. The results indicated a dominant river source for Zn, Al diluting effect on Pb Ni. truly dissolved fraction kDa) dominated Ni Co pool, large part p...
پروتئین های غیر اختصاصی انتقال دهنده لیپید (nsltps) در گیاهان، پروتئین های بازی کوچکی هستند که فسفولیپیدها را بین غشاءها جابه جا می کنند و به دو زیرخانواده ( kda 9) ltp1 و ( kda 7) ltp2 تقسیم می شوند. به منظور تخلیص ltp1، ابتدا آرد برنج شلتوک دار عصاره گیری شد. پروتئین های عصاره توسط آمونیم سولفات رسوب داده شد. اکتینیدین اضافه و از ستون کربوکسی متیل- سفارز عبور داده شد. جهت تحریک سیستم ایمنی خر...
We have cloned and characterized novel oxygenolytic ortho-dehalogenation (ohb) genes from 2-chlorobenzoate (2-CBA)- and 2,4-dichlorobenzoate (2,4-dCBA)-degrading Pseudomonas aeruginosa 142. Among 3,700 Escherichia coli recombinants, two clones, DH5alphaF'(pOD22) and DH5alphaF'(pOD33), converted 2-CBA to catechol and 2,4-dCBA and 2,5-dCBA to 4-chlorocatechol. A subclone of pOD33, plasmid pE43, c...
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