We report for the first time the use of a selective small-molecule inhibitor of DNA repair to potentiate topoisomerase II (topo II) poisons, identifying DNA-dependent protein kinase (DNA-PK) as a potential target for leukemia therapy. Topo II poisons form cleavable complexes that are processed to DNA double-strand breaks (DSBs). DNA-PK mediates nonhomologous end joining (NHEJ). Inhibition of th...

sooner, especially as I have additional experiences on the subject, which I trust will prove not valueless. I regret that carelessness in punctuating should h;iva had such an effect on " Alpha", as 1 can easily see that it has caused him to have many misconceptions with regard to the matter contained in the paper. I will try and remedy some of them now, and as I suppose he has put most of his d...

In an age of climate change, researchers need to form a deepened understanding of the determinants of environmental concern, particularly in countries of emerging economies. This paper provides a region-specific investigation of the impact of socio-economic status (SES) and objective environmental conditions on environmental concern in urban Brazil. We make use of data that were collected from ...

OBJECTIVE The first democratic government elected in South Africa in 1994 inherited huge inequalities in health status and health provision across all sections of the population. This study set out to assess, 4 years later, the influence of race and socioeconomic status (SES) on perceived quality of care from health care providers. DESIGN A 1998 countrywide survey of 3820 households assessed ...

OBJECTIVES The first democratic government elected in South Africa in 1994 inherited huge inequities in health status and health provision across all sections of the population. This study set out to assess the impact of the new government's commitment to address these inequities and implement policies to improve population health in general and address inequalities in health care in particular...

many reports have indicated the medical importance of animal poisons in iran. the significance numbers of iranians are injured from high endemic to sporadic, by venomous snakes, scorpions, wasps, bees, fire and velvet ants, spiders and backswimmer bugs, so their nuisance prevention is an important task.

The magnitude of provider uncompensated care has become an important public policy issue. Yet existing measures of uncompensated care are flawed because they compare uninsured payments to list prices, not to the prices actually paid by the insured. We address this issue using a novel source of data from a vendor that processes financial data for almost 4000 physicians. We measure uncompensated ...