In order to improve the sensitivity of cervical cancer cells to irradiation therapy, we targeted hexokinase 2 (HK2), the first rate-limiting enzyme of glycolysis, and explore its role in cervical cancer cells. We suppressed HK2 expression and/or function by shRNA and/or metformin and found HK2 inhibition enhanced cells apoptosis with accelerating expression of cleaved PARP and caspase-3. HK2 in...

OBJECTIVES The aims of this study were to investigate the functions of GAS5 as a tumor suppressor in cervical cancer and explore the mechanism. METHODS The expression of GAS5 and microRNA 21 (miR-21) was detected in primary cervical cancer tissue specimens, as well as in cervical cancer cell lines. We identified the interaction of GAS5 and miR-21 by quantitative polymerase chain reaction, Wes...

background: autophagy suppression recently has been known to have a remarkable effect for cellular adjustment and viability in the final stages of cancer. on the other hand, autophagy has the potential effect in preventing many viruses from replication. beclin1 is the most substantial constituent in autophagy apparatus regulation. this study was intended to investigate the beclin1 sirna knockdo...

Pharmacognosy Research,2022,14,4,499-503.DOI:10.5530/pres.14.4.72Published:October 2022Type:Original ArticleAuthors:Amir Saeed, and Ahmed Alharbi Author(s) affiliations:Amir Saeed1,2, Alharbi1 1Department of Medical Laboratory Sciences, College Applied University Hail, KSA. 2Department Microbiology, Faculty Sciences Technology, Khartoum, SUDAN. Abstract:Background: Cervical cancer is widely ack...

background : cancer stem cells are a subgroup of tumor cells that have the capability for self-renewal and differentiation and are characterized by multiple markers. several studies have been conducted to identify these cells in colorectal cancer, including stem cell marker cd24. this study has evaluatedtheassociation of cd24 expression with clinicopathologic features and survival in an immunoh...

Cervical cancer is the third most common cancer in women worldwide. However, the underlying mechanism of occurrence and development of cervical cancer is obscure. In this study, we observed that miR-30e was downregulated in clinical cervical cancer tissues and cervical cancer cells. Next, overexpression of miR-30e reduced the cervical cancer cell growth through MTT, colony formation, EdU, and T...

This work presents the design and simulation of an all-optical sensor for detection cancer cells. The proposed device is based on surface plasmon resonance effect a spiral shaped photonic crystal fiber structure. finite element method (FEM) simulations are carried out different cells, such as HELA, Basal, Jurkat, MDA-MB-231, MCF7, PC12 detection. has shown maximum sensitivity ?289 RIU?1 refract...

Background and Aim: Cervical and breast cancer are considered to be the most common cause of death among Iranian women. Various studies have shown that probiotics are effective fighting cancer. The aim of the present study was to investigate the effect of Lactobacillus brevis on apoptosis and casp (casp3, casp8) gene expression in HeLa cancer cells.  Materials and Methods: In this study, L. br...

BACKGROUND Cervical cancer is one of the leading causes of cancer-related death in woman worldwide. In the present study, we investigated the role of microRNA 664 (miR-664) in regulating cancer migration and chemotherapy sensitivity in cervical cancer. METHODS Quantitative real-time PCR (qPCR) was used to assess the mRNA levels of miR-664 in both cervical cancer cell lines and cancer tissues ...