PURPOSE To investigate the long-term outcome of keratolimbal allograft (KLAL) for the treatment of severe ocular surface disorders. DESIGN Retrospective, noncomparative case series. PARTICIPANTS Twenty patients (23 eyes) with severe ocular surface disorders. INTERVENTION Thirty-three KLAL procedures were performed. Ten patients (10 eyes) underwent KLAL in combination with other surgical p...

The cornea is a central component of the camera eye of vertebrates and even slight corneal disturbances severely affect vision. The transcription factor PAX6 is required for normal eye development, namely the proper separation of the lens from the developing cornea and the formation of the iris and anterior chamber. Human PAX6 mutations are associated with severe ocular disorders such as anirid...

The leading topic of this particular paper is dedicated to available surgical options for refractive eye disorders treatment including surgery of cornea and intraocular surgery. Corneal Surgery includes laser refractive surgery - LASIK (Laser-Assisted In Situ Keratomileusis), FemtoLASIK (Femtosecond laser-assisted LASIK), PRK (Photorefractive keratectomy). This article describes relevant princi...

Purpose To determine the presence of monocarboxylate transporter (MCT) in human and rabbit corneal epithelium and its role in transcellular fluorescein transportation in the cornea. Methods The presence of MCTs in human and rabbit corneal epithelium was determined by RT-PCR and immunohistochemistry. Intracellular fluorescein uptake experiment was performed using cultured human corneal epithel...

Neurotropic keratopathy is one of the major refractory corneal disorders, which was first recognized in 1824. This category of diseases is caused by damage to the trigeminal nerve and the consequent loss of corneal sensation. It leads to various types of corneal disorder, including superficial keratopathy, persistent epithelial defects and corneal ulcers. In the present article, we review the p...

Vps35 (vacuolar protein sorting 35) is a major component of retromer that selectively promotes endosome-to-Golgi retrieval of transmembrane proteins. Dysfunction of retromer is a risk factor for the pathogenesis of Parkinson's disease (PD) and Alzheimer's disease (AD). However, Vps35/retromer's function in the eye or the contribution of Vps35-deficiency to eye degenerative disorders remains to ...

PURPOSE To evaluate the clinical value of rigid gas permeable contact lenses in children after traumatic corneal scarring. METHODS This comparative study included 15 children (age range: 5.7 to 14 years; mean ± standard deviation = 9.4 ± 2.9 years) with corneal scars and best corrected visual acuity (BCVA) of worse than 20/20, history of penetrating ocular trauma, and/or cataract extraction. ...

Surgical Indications • Congenital corneal disorders • Corneal dystrophies • Corneal degenerations • Corneal scarring/opacifi cation – Infection – Infl ammation – Trauma • Graft failure • Corneal decompensation – Pseudophakic – Aphakic – Iatrogenic – Dystrophic – Traumatic Surgical Instrumentation • Operating microscope • Microsuturing instruments – Fine-toothed 0.12-mm forceps – Fine-tip needle...

Squamous metaplasia is an abnormal epithelial differentiation represented on the ocular surface by a spectrum of skin-like changes of conjunctival and corneal epithelium. This pathologic condition can be observed in a variety of ocular surface disorders, including systemic vitamin A deficiency and cicatricial keratoconjunctivitis. We recently encountered a patient with a progressively enlarging...