objective: patients over 60 years of age have higher mortality and morbidity after major liver resections. nitric oxide (no) derived from the catalytic activity of nos2 plays a beneficial role in liver regeneration (lr) after partial hepatectomy (ph). in this experiment, we evaluated the effect of nos2 knockout (ko) on lr in aged mice after ph. materials and methods: in this cohort study, 52 tw...

introduction: emergency department thoracotomy (edt) may serve as the last survival chance for patients who arrive at hospital in extremis. it is considered as an effective tool for improvement of traumatic patients’ outcome. the present study was done with the goal of assessing the outcome of patients who underwent edt and its predictive factors. methods: in the present study, medical charts o...

conclusions we can conclude that the surveillance presented to our injured group probably had some defects that need to be revised in therapeutic services to enhance survival requirements. objectives the aim of this study was to evaluate the outcome of trauma cases using the trauma score and the injury severity score (triss) model and then comparing this with the results of a major trauma outco...

Background: To determine the expression of cancer stem cell marker Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) in colorectal carcinoma samples compared to normal adjacent tissue and any possible association with clinicopathological findings. Methods: This study was performed on forty samples of cancerous colorectal tissues (case group) and their adjacent normal mucosa (c...

Background: The survival of patients with triple-negative breast cancer subtype undergoing chemotherapy along weight management, physical activity, and diet was examined. In addition, the relationship between Overall Survival (OS) expression P53 Ki 67 investigated. Methods: study conducted on 110 admitted to oncology clinics October 2009 July 2018. underwent five cycles, including Docetaxel, Ep...

introduction: gastric cancer remains the second most common cause of cancer-related deaths worldwide. in many malignancies like, lung and breast, multiple prognostic factors are known, such as mutations in ki-67, her-2/neu, p53. in this study, we evaluated immunohistochemical protein expression patterns of cell-cycle-regulators p53, proliferation marker ki-67, surface expression of cd44, her-2/...

Introduction: Metalloproteinases and their tissue inhibitors play an important role in the metastases formation. A multistage process of carcinogenesis requires the involvement of numerous enzymes and compounds that facilitate the expansion of tumor cells. The formation of metastases depends on both metalloproteinases and tissue inhibitors activation leading to the acti...