Cofilin and its closely related protein, actin-depolymerizing factor (ADF), are key regulators of actin cytoskeleton dynamics that have been implicated in growth cone motility and neurite extension. Cofilin/ADF are inactivated by LIM kinase (LIMK)-catalyzed phosphorylation and reactivated by Slingshot (SSH)-catalyzed dephosphorylation. Here we examined the roles of cofilin/ADF, LIMKs (LIMK1 and...

FastFlow is a structured parallel programming framework targeting shared memory multi-core architectures. In this paper we introduce a FastFlow extension aimed at supporting also a network of multicore workstations. The extension supports the execution of FastFlow programs by coordinating–in a structured way–the fine grain parallel activities running on a single workstation. We discuss the desi...

BACKGROUND In Ethiopia, children and mothers have been facing several health problems due to poor access to modern health care facilities and lack of effective demand to utilize the available ones. In response to this, the Ethiopian government initiated the health extension program in 2003 to improve equity in access to preventive, promotive and selected curative health interventions through he...

Blended solutions provide a means to orchestrate various types of activities and to schedule interactions at different times, nonetheless it is difficult to maintain a general overview of the class. In this paper, we build on the LearnWeb Design Framework to design and implement a Formative Assessment extension that supports the monitoring of the learning process in order to increase awareness ...

Applied research in graph algorithms and combinatorial structures needs comprehensive and versatile software libraries. However, the design and the implementation of flexible libraries are challenging activities. Among the other problems involved in such a difficult field, a very special role is played by graph classification issues. We propose new techniques devised to help the designer and th...

Applied research in graph algorithms and combinatorial structures needs comprehensive and versatile software libraries. However, the design and the implementation of flexible libraries are challenging activities. Among the other problems involved in such a difficult field, a very special role is played by graph classification issues. We propose new techniques devised to help the designer and th...

Emissions resulted from transportation activities may lead to dangerous effects on the whole environment and human health. According to sustainability principles, in recent years researchers attempt to consider the environmental burden of logistics activities in traditional logistics problems such as vehicle routing problems (VRPs). The pollution-routing problem (PRP) is an extension of the VRP...

The purpose of this discussion paper is to examine approaches for extending the ADL SCORM standard with additional metadata based on ADL approved methods. An introduction to the ADL SCORM standard is presented followed by a description of the SCORM components. Examples of how SCORM is lacking LOM in the areas pedagogy, adaptive learning and learning assessment data are then discussed. According...

Tenodesis refers to opposition of the thumb and index finger with either active or passive wrist extension. Achieving a functional tenodesis grasp is a primary focus of therapy for such a person, to enable participation in activities of daily living. Tenodesis grasp is achieved with people who have a complete C6 level of quadriplegia, using a range of clinical interventions: passive wrist and h...