celecoxib is classified as none traditional nonsteroidal anti-inflammatory drugs (nsaids). this compound has conventional properties of nsaids such as anti-inflammatory, analgesic, and antipyretic activities beside reduced risk of gastrointestinal side effect of traditional nsaids such as ibuprofen. this compound gets a second sale rank of nsaids market at 2016 in the world and sales more than ...

The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-di...

a simple and efficient one-pot method for the preparation of aromatic iodides has been developed by sequential diazotization–iodination of aromatic amines employing sodium nitrite and sodium iodide in the presence of acidic ionic liquid n-methyl-2-pyrrolidonum hydrosulfate ([h-nmp]hso4). the diazonium salts that are formed by this ionic liquid are stable at room temperature and react rapidly wi...

A practical and green synthesis of 3-substituted indoles is reported via three-component coupling reaction of indoles, aldehydes and N-methylaniline in the presence of the acidic ionic liquid 1-butyl-3-methylimidazolium hydrogen sulfate ([BMIm]HSO4) under ultrasound irradiation at room temperature. The significant features of this procedure are high yields of the products, simple work-up, opera...

In this research, the reactive absorption of carbon dioxide in an aqueous solution of NH3, H2O, and NaOH has experimentally been investigated. The experiments were carried out in an absorption pilot plant in different operational conditions. The composition and temperature of both gas and liquid phases were obtained during the column height. The concentration of molecular ...

Studying the interaction of pharmaceutical ionic liquids with human serum albumin (HSA) can help investigating whether or not ionic liquid formation can enhance pharmacological profile of the discrete ingredients. In this respect, in the present work, the interactions of Benzalkonium Ibuprofenate, as a well-known active pharmaceutical ionic liquid, Benzalkonium Chloride, and also Sodium Ibuprof...

Ionic liquid N-ethylpyridinium hydrogen sulfate has been prepared, characterized and used as an efficient recyclable catalyst for the synthesis of a series of indoles and bis(indolyl)methanes. Latter have been further explored for their potential antimicrobial activity against E coli and Bacillus. The ionic liquid used was recycled in the end and its recovery was facilitated b...

Several novel palladium triphosphine complexes have been synthesized and tested as recyclable catalysts for the methoxylation of alkynes into acetals in ionic liquids. A complete conversion of phenylacetylene was achieved with only 0.2% of [Pd(Triphos)NCMe][(PF6)2] in a methanol/[BMIM][BF4] mixture. We discovered that the addition of an ionic liquid to methanol allowed not only to increase the ...

a homogeneous ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate doped with licl ([bmim]bf4-licl) was found as catalyst solvents for the synthesis of dicoumarols by the condensation of 4-hydroxycoumarin and aldehyde at 80 ˚c. in this field, several types of aromatic aldehyde, containing electron-withdrawing groups as well as electron-donating groups, were rapidly changed to the correspo...