Asymmetric distribution of proteins and other molecules within cells leads to cell polarization. One of the most studied examples occurs in epithelial cells that polarize to form apical and basolateral surfaces (Nelson, 2003). Although we know much about directed protein trafficking after cells are polarized, less is known about the initial mechanisms that lead to polarization. Genetic and bioc...

In this issue of Neuron, Xie et al. (2013) identified protein phosphatase 4c (PP4c) as a new component in the regulation of spindle orientation during mammalian neurogenesis. Importantly, their findings uncovered a novel and critical temporal aspect of the regulation of spindle orientation during neurogenesis.

Mobile technologies and more precisely apps have disrupted technology scenario. Bring your own application (BYOA) is a new trend that has emerged after the “bring your own device” (BYOD) vogue. However, and in spite of its intrinsic benefits, the trend presents also several caveats and Enterprise app stores are seen as a way to tackle these risks. In this paper, authors present ModEAS, a system...

Social reformers such as John Stuart Mill and John Dewey have long expressed concern about a tension between democratic principles and organizational practices that appear undemocratic.' More recently, a substantial body of academic literature advocating changes in organizations to make them more democratic has been produced.2 Change has been advocated on a variety of normative grounds. In a no...

in this paper, surface and piezoelectric effects on the vibration behavior of nanowires (nws) are investigated by using a timoshenko beam model. the electric field equations and the governing equations of motion for the piezoelectric nws are derived with the consideration of surface effects. by the exact solution of the governing equations, an expression for the natural frequencies of nws with ...

statins are most effective pharmacologically agents to decrease total plasma cholesterol level by competitive inhibition of hmg-co a reductase. apart from the well-known ldl and cholesterol lowering effect, statins have been postulated to exert other beneficial effects also called pleotropic or non-lipid effects. better understanding of various pleotropic effects of statins has prompted a new s...

Landscape groundcover plants are a diverse group of trailing or spreading species that naturally form continuous soil coverage.Ground cover plants that were used in this study consisted of vegetative propagules of: Vinca minor L. ٬Variegatum’, Vinca minor L. ٬Green’, Oxalis brasiliensis G. Lodd, Trifolium repens L., Phyla nodiflora L. and Frankenia thymifolia Desf. The aim of this study was to ...

Mycobacterium bovis (M. bovis), the causative agent of bovine tuberculosis, has been identified in nine geographically distinct wildlife populations in North America and Hawaii and is endemic in at least three populations, including members of the Bovidae, Cervidae, and Suidae families. The emergence of M. bovis in North American wildlife poses a serious and growing risk for livestock and human...