This paper discusses pricing strategies and production of upstream and downstream firms from the view of a principal-agent relationship. As an agent, the upstream firm offers intermediate products and allocates them between downstream firms according to their incentives. As principals, downstream firms determine the quantities of final products they separately supply based on the competition or...

Currently, statins are the only drugs acting on the mammalian isoprenoid pathway. The mammalian genes in this pathway are not easily amenable to genetic manipulation. Thus, it is difficult to study the effects of the inhibition of various enzymes on the intermediate and final products in the isoprenoid pathway. In fission yeast, antifungal compounds such as azoles and terbinafine are available ...

Experimental evidence for a 5-exocyclic methylene-dUMP intermediate in the thymidylate synthase reaction was recently obtained by demonstrating that tryptophan 82 mutants of the Lactobacillus casei enzyme produced 5-(2-hydroxyethyl)thiomethyl-dUMP (HETM-dUMP) (Barret, J. E., Maltby, D. A., Santi, D. V., and Schultz, P. G. (1998) J. Am. Chem. Soc. 120, 449-450). The unusual product was proposed ...

Abstract An affine de Casteljau type algorithm to compute q−Bernstein Bézier curves is introduced and its intermediate points are obtained explicitly in two ways. Furthermore we define a tensor product patch, based on this algorithm, depending on two parameters. Degree elevation procedure is studied. The matrix representation of tensor product patch is given and we find the transformation matri...

Professors Nasser and Turcic designed a model using game theory to analyze different types of firms, their supply chain options, and the choices they make when it comes to controlling output. Firms fall into one of three categories based on product differentiation in their industry: low, intermediate, or high product differentiation. Findings show that competing firms in an industry with low pr...

The electrochemical reduction mechanism of ethidium bromide was first studied by spectroelectrochemistry. This reduction was proved to be a two-step process by cyclic voltammetry, differential pulse voltammetry and spectroelectrochemistry, in which each step was proved to be a one-electron transfer process by a spectropotentiostatic fluorescence technique. Hydroethidine was confirmed to be the ...

degradation of o,o-dimethyl -o-4-nitrophenylphosphorothioate (methylparathion) by ozonation in aqueous solution was studied in a batch reactor under constant ozone dosage and variable ph conditions. the effectiveness of the process was estimated based on the degree of cod (chemical oxygen demand) reduction and conversion of methylparathion. it was observed that ozonation is more effective at a...

Attempted oxidation of a TADDOL-derived bisthioacetate resulted in a rather unexpected and remarkable cyclization and deprotection reaction, giving a thiolane-1, 1-dioxide as the main product. Systematic in situ ESI-HRMS studies revealed a bicyclic, highly acid labile key intermediate of this reaction. Supported by force field calculations, the high sensitivity of this intermediate was judged t...

A base-promoted formal arylation of benzo[d]oxazoles with acyl chloride was achieved in moderate to good yields. This reaction was triggered by the N-acylation of oxazole to form an iminium intermediate. Then, the addition of H2O to the iminium formed the hemiacetal intermediate. After the sequential ring-opening, extrusion of CO, the ring closure, the dehydration delivered the formal arylation...