Plants contain a flavonoid called naringin, which has variety of medicinal uses. Tomatoes, grapefruits, and other citrus fruits the flavanone glycoside known as 4′,5,7-trihydroxyflavanone-7-rhamnoglucoside. There are seven enzyme-catalyzed stages in phenylpropanoid route, runs from phenylalanine to prunin. Naringin possesses anti-inflammatory, anti-tumor, antioxidant effects. been shown have im...

Osteoporosis has become one of the most prevalent and costly diseases in the world. It is a metabolic disease characterized by reduction in bone mass due to an imbalance between bone formation and resorption. Osteoporosis causes fractures, prolongs bone healing, and impedes osseointegration of dental implants. Its pathological features include osteopenia, degradation of bone tissue microstructu...

Objective(s): Bisphenol A (BPA) as a synthetic compound is applied in many plastic industries. BPA has been reported to have endocrine-disrupting feature with cytotoxic effects. The study aimed to evaluate the efficiency of Naringin against testicular toxicity induced by BPA in adult rats.Materials and Methods: The animals were assigned into six groups of control, BPA-treated (50 mg/kg), BPA+Na...

Naringin is a flavonoid glycoside found in citrus fruits and grapes with wide range of therapeutic actions. We aimed to study the inotropic effect naringin on rat-isolated atria, dissecting intracellular mechanisms involved this response. Concentration-response curves (0.003-6 mM) were obtained before after pre-incubation selective antagonists. Our results showed that presented biphasic respons...

BACKGROUND Metals can cause male infertility through affection of spermatogenesis and sperm quality. Strong evidences confirm that male infertility in metal-exposed humans is mediated via various mechanisms such as production of reactive oxygen species (ROS). Flavonoids have antioxidant and metal chelating properties which make them suitable candidates for neutralizing adverse effects of metals...

Citrus aurantium is rich in flavonoids, which may prevent osteosarcoma progression, but its related molecular mechanism remains unclear. Flavonoids were extracted from C. aurantium and purified by reparative HPLC. Each fraction was identified by using electrospray ionisation mass spectrometry (ESI-MS). Three main components (naringin, naringenin, and hesperetin) were isolated from C. aurantium....

Flavanones (hesperidin, naringenin, naringin, and poncirin) in industrial, hand-squeezed orange juices and from fresh-in-squeeze machines orange juices were determined by HPLC/DAD analysis using a previously described liquid-liquid extraction method. Method validation including the accuracy was performed by using recovery tests. Samples (36) collected from different Brazilian locations and bran...