نتایج جستجو برای: over expression
تعداد نتایج: 1958911 فیلتر نتایج به سال:
Background: Cholera toxin B subunit (CTB) has been extensively considered as an immunogenic and adjuvant protein, but its yield of expression is not satisfactory in many studies. The aim of this study was to compare the expression of native and mutant recombinant CTB (rCTB) in pQE vector. Methods: ctxB fragment from Vibrio cholerae O1 ATCC14035 containing the substitution of mutant ctxB for ami...
Introduction : Breast cancer is the most common cancer and the second cause of cancer death among women. Despite recent developments in therapeutic tools about 25% of all the involved cases die annually. The clinical, molecular, and pathologic features of breast cancer in BRCA1 mutation carriers suggest that BRCA1 may function as a stem-cell regulator. The purpose of the current study was to ...
Background: Myogenin (MyoG) and Myostatin (Mstn) play role in muscle growth and wasting, respectively. The present study aimed to investigate the combined effect of High-intensity Interval Training (HIIT) and Metformin drug (Metf) on gene expression of MyoG and Mstn in skeletal muscle of type 2 diabetic mice. Methods: 25 mice (C57BL/6) were assigned to two groups, including 1) Control © (n=5),...
Background: In gene therapy, the use of RNA molecules as therapeutic agents has shown advantages over plasmid DNA, including higher levels of safety. However, transient nature of RNA has been a major obstacle in application of RNA in gene therapy. Methods: Here, we used the internal ribosomal entry site of encephalomyocarditis virus and the 3’ non-translated region of Poliovirus to design an en...
throughout this dissertation r is a commutative ring with identity and m is a unitary r-module. in this dissertation we investigate submodules of multiplication , prufer and dedekind modules. we also stat the equivalent conditions for which is ring , wher l is a submodule of afaithful multiplication prufer module. we introduce the concept of integrally closed modules and show that faithful mu...
مقدمه: her-2 یک گیرنده پروتئینی فاکتور رشد است. حدود 25% سرطان های پستان، بیان بیش از حد (over expression) her-2 دارند. این مطالعه به منظورتعیین فراوانی نسبی her-2 over expression در بیماران مبتلا به سرطان پستان و ارتباط آن با متغیرهایی از قبیل سن، تشخیص هیستوپاتولوژی، سایز تومور، درگیری غدد لنفاوی انجام شد. روش بررسی: در این مطالعه تحلیلی – توصیفی همه بیمارانی که نمونه بافت سرطان پستان آنها در...
odontogenic keratocysts (okcs) are one of the most frequent features of nevoid basal cell carcinoma syndrome (nbs). it is linked with mutation in the ptch gene. partial expression of the gene may result in occurrence of only multiple recurring okc. our patient presented with nine cysts with multiple recurrences over a period of 11 years without any other manifestation of the syndrome.
background: sustainable and commercial production of taxol as an anti cancer drug is a critical point to its clinical application. nowadays, hazel because of rapid growth and wide range distribution is considered as an alternative source of taxol. objective: to increase taxol production the cdna encoding 3-hydroxy-3-methylglutaryl-coa reductase (hmgr) from iranian hazel (genebank accession numb...
Background: Spermatogenesis is a complex and highly organized process of proliferation and differentiation of spermatogonial stem cells. Spermatogonial stem cells (SSCs) as a unique stem cell have the potential to self-renewal, differentiation and transmit genetic information to the next generation and play a vital role in maintaining fertility. Sertoli cells as the only somatic cells within th...
background: the wilm’s tumor gene 1 (wt1) encodes a zinc finger transcription factor that is inactivated in a subset of wilm’s tumors. it plays a crucial role in growth, proliferation and development of some embryonic and adult organs. wt1 is expressed as a tumor associated antigen (taa) in various types of solid and hematopoietic malignancies and can be employed as a useful marker for targeted...
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