Background: Intensity-modulated radiotherapy (IMRT) is one of the most usable methods in prostate radiotherapy that is used with different techniques. The aim of this study was to evaluate and compare the dosimetric and radiobiological effects of prostate IMRT techniques regarding to joint volume between the target tissue and organs at risk as a patients anatomical parameter. Methods: This res...

A dose and dose-rate effectiveness factor (DDREF) for low-linear energy transfer (LET) radiations (photons and electrons) is used in cancer risk assessments to represent an assumption that risks at low doses and low dose rates may be less than estimates that are based mainly on linear extrapolations of observed risks at higher acute doses. DDREF generally is assumed to be independent of energy....

A novel and versatile "bottom-up" approach is developed to estimate the radiobiological effect of clinic radiotherapy. The model consists of multi-scale Monte Carlo simulations from organ to cell levels. At cellular level, accumulated damages are computed using a spectrum-based accumulation algorithm and predefined cellular damage database. The damage repair mechanism is modeled by an expanded ...

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BACKGROUND There is wide interest in the use of intravascular irradiation to control restenosis following balloon angioplasty. Part of the mechanism of restenosis appears to be the proliferation of smooth muscle cells (SMCs), triggered to divide by the damage caused by the angioplasty, and this proliferation can be inhibited by irradiation with y-rays or beta-rays. METHODS In vitro data for t...