background: to explain the role of arthroscopic release in intractable frozen shoulders. we used different questionnaires and measuring tools to understand whether arthroscopic release is the superior modality to treat patients with intractable frozen shoulders. methods: between 2007 and 2013, in a prospective study, we enrolled 80 patients (52 females and 28 males) with recalcitrant frozen sho...

Objective(s): This study was designed to investigate the effect of receptor for advanced glycation end products (RAGE), S100A12 and C-reactive protein (CRP) on the release of circulating endothelial cells (CECs) from human coronary artery endothelial cells (HCAECs). Materials and Methods: HCAECs were cultured in increasing concentration of CRP (0, 12.5, 25, 50μg/ml) or S100A12 protein (0, 4, 1...

The desire of companies to offer same-day delivery leads to interesting new routing problems. We study the complexity of a setting in which a delivery to a customer is guaranteed to take place within a pre-specified time after the customer places the order. Thus, an order has a release date (when the order is placed) and a deadline (when the order needs to be delivered). A vehicle delivering an...

extended release formulation of alfuzosin, an a-antagonist used for prostatic hypertrophy, is available in market. it is convenient for older patients to take only one tablet a day. marketed alfuzosin formulation is three layered geomatrix tablet that requires special facilities, high cost, more time and complex operation than normal direct compression formulation. therefore, a less complicated...

sustained release oral delivery systems are designed to achieve therapeutically effective concentrations of drug in the systemic circulation over an extended period of time. the purpose of the present investigation was to design and evaluate sustained release matrix tablets of nifedipine, a poorly water soluble drug, employing hydroxypropyl methyl cellulose ( hpmc) and ethyl cellulose ( ec) as ...