Hippocampal lesions often produce temporally graded retrograde amnesia (TGRA), whereby recent memory is impaired more than remote memory. This finding has provided support for the process of systems consolidation. However, temporally graded memory impairment has not been observed with the watermaze task, and the findings have been inconsistent with context fear conditioning. One possibility is ...

Although animal models of Alzheimer's disease (AD) recapitulate beta-amyloid-dependent hippocampal synaptic and cognitive dysfunctions, it is poorly understood how cortex-dependent remote memory stabilization following initial hippocampal coding is affected. Here, we systematically analyzed biophysical and behavioral phenotypes, including remote memory functions, of 5XFAD APP/PS1 transgenic mic...

Recall of remote episodic memory was assessed in three types of amnesic patient whose remote semantic memory had been evaluated previously. Patients with Korsakoff's syndrome, case N.A. and patients receiving electroconvulsive therapy all succeeded in recalling specific autobiographical episodes in response to single-word cues, and in many conditions performed as well as control subjects. Their...

Thread migration is one approach to remote memory accesses on distributed memory parallel computers. In thread migration, threads of control migrate between processors to access data local to those processors, while conventional approaches tend to move data to the threads that need them. Migration approaches enhance spatial locality by making large address spaces local, but are less adept at ex...

Process checkpointing is a procedure which periodically saves the process states into stable storage. Most checkpointing facilities select hard disks for archiving. However, the disk seek time is limited by the speed of the read-write heads, thus checkpointing process into a local disk requires extensive disk bandwidth. In this paper, we propose an approach that exploits the memory on idle work...

The dentate gyrus (DG), a hippocampal subregion, continuously produces new neurons in the adult mammalian brain that become functionally integrated into existing neural circuits. To what extent this form of plasticity contributes to memory functions remains to be elucidated. Using mapping of activity-dependent gene expression, we visualized in mice injected with the birthdating marker 5-bromo-2...