Hyperosmolar saline has been used for many years for sputum induction as an aid to diagnosing lower respiratory infections, especially tuberculosis.1 More recently 7% saline has been used as a therapeutic aerosol to assist airways clearance in persons with cystic fibrosis (CF) and non-CF bronchiectasis. Studies have shown that the regular, twice daily inhalation of 7% saline aerosol is safe for...

BACKGROUND Doxorubicin is an anthracycline antibiotic commonly used to treat a variety of cancers as a most effective antitumor. However, its clinical use is associated with the toxic effects in numerous healthy tissues. Here we investigated the pretreatment effect of regular aerobic exercise on oxidative stress in rats acutely exposed to DOX-induced hepatotoxicity. MATERIALS AND METHODS Fort...

The objective of the present study was to investigate whether creatine (Cr) could attenuate the deleterious effects of high doses of dexamethasone (Dexa) on body mass, exercise performance, and respiratory variables of rodents. Forty-four Wistar rats performed incremental maximal exercise tests. They were then assigned to four groups: G1: subcutaneous (s.c.) and intraperitoneal (i.p.) saline; G...

Introduction: Memantine (MEM) is a noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist clinically used for the treatment of Alzheimer disease (AD) in mild to severe conditions. The present study was conducted to investigate the effects of memantine on the spontaneous firing frequency of CA1 pyramidal neurons in rats caused by an electrical lesion of Nucleus Basalis Magnocellularis (...

the aim of this study was to investigate the effect of acute plyometric exercise with and without vitamin c supplementation on serum bdnf concentration in inactive men. in this semi-experimental study, 36 inactive men were randomly divided into four groups: vitamin+exercise (combination), vitamin c, exercise, and control. the exercise and combination groups performed the selected plyometric pro...