This communication reports a comparison of the chemical constitution of affected and unaffected regions of white matter in the spinal cords of Friedreich's ataxia and motor neurone disease (MND). Friedreich's ataxia is a member of the heredo-familial spino-cerebellar diseases, the mode of inheritance being mainly recessive. Most cases of MND in Europe have no family history (Spillane, 1962) and...

Degenerative spinal motor diseases, like amyotrophic lateral sclerosis, are produced by progressive degeneration of motoneurons. Their clinical manifestations include a progressive muscular weakness and atrophy, which lead to paralysis and premature death. Current pharmacological therapies fail to stop the progression of motor deficits or to restore motor function. The purpose of our study was ...

Background: As a novel pro-apoptotic kinase, Mammalian sterile 20–like kinase 1 (Mst1) promotes programmed cell death in animal models of inflammatory diseases. This research aimed to determine the level of expression of Mst1 gene in a rat model of spinal cord injury (SCI) treated with valproic acid (VPA). Methods: Animals were divided into four groups: Contused animals (untreated); laminectom...

  Background :Cell-based therapies can be used to treat neurological diseases and spinal cord injuries. The aim of this study was to assess the clinical outcome of bone marrow derived mononuclear cells (BM-MNCs) transplantation in patients with spinal cord injuries.   Method s: Following a systematic review to detect clinical intervention studies, a meta-analysis was done for pooling data to es...

background :cell-based therapies can be used to treat neurological diseases and spinal cord injuries. the aim of this study was to assess the clinical outcome of bone marrow derived mononuclear cells (bm-mncs) transplantation in patients with spinal cord injuries.   method s: following a systematic review to detect clinical intervention studies, a meta-analysis was done for pooling data to esti...

spinal cord injury (sci) is a destructive condition that the cord can't send signals below the level of the injury. despite advances in the medical and surgical care of sci patients, no effective treatment exists for the neurological deficits of sci. cell therapy is a new approach for sci, and preclinical models demonstrate that cell transplantation can improve some secondary events throug...

provided the original work is properly cited. CC A spinal cord stimulator is usually used as an electro-modulator for pain treatment. Shealy et al. [1] first reported the use of a spinal cord stimulator in an elderly male suffering with terminal bronchogenic carcinoma and right-sided chest pain in 1967. Since then, spinal cord stimulation (SCS) has been applied to many disease entities, such as...