Introduction . The concept of the interaction multidirectional cytokines that control cellular and humoral immune response in cold bronchospasm asthma has been little studied. Aim To evaluate role Th1 Th2 formation airway to a stimulus patients with asthma. Materials methods spectrum (IFN-γ, IL-17А, TNFα, IL-1β, IL-2, IL-6, IL-4), protein IP-10 (chemokine CXCL10), MMP9 metalloproteinase TIMP1 e...

Mục tiêu: Nghiên cứu nồng độ IL-2, IL-4, IL-6, IL-8, IL-10, IL-17, TNF-α, INF-γ trong bệnh vảy nến đỏ da toàn thân (VNĐDTT) tại Bệnh viện Da liễu Trung ương. Đối tượng và phương pháp nghiên cứu: Tiến cứu, mô tả cắt ngang có đối chứng so sánh với 30 nhân VNĐDTT (nhóm bệnh-NB) không chống chỉ định dùng Methotrexate người khỏe mạnh chứng-NĐC) tương đồng về tuổi giới. Kết quả: Trước điều trị: Nhóm ...

IL-12 and IL-23 regulate innate and adaptive immunity to microbial pathogens through influencing the expression of IFN-γ, IL-17, and IL-22. Herein we define the roles of IL-12 and IL-23 in regulating host resistance and intestinal inflammation during acute Salmonella infection. We find that IL-23 alone is dispensable for protection against systemic spread of bacteria, but synergizes with IL-12 ...

OBJECTIVE The Mycobacterium bovis Bacillus Calmette-Guerin (BCG) neonatal vaccination inhibits allergy-induced pathologic changes. However, the mechanisms underlying this process are unclear. This study aimed to investigate the role of interferon (IFN)-γ and interleukin (IL)-17 in the protective effects of the BCG neonatal vaccination on allergic pulmonary inflammation and airway hyperresponsiv...

Background: Discriminating latent tuberculosis infection (LTBI) from active TBI may be challenging. The objective of this study was to produce the recombinant L-alanine dehydrogenase (AlaDH) antigen and evaluate individuals with LTBI, those with active TBI, and uninfected individuals by enzyme-linked immunospot assay (ELISPOT) in order to distinguish LTBI from active TBI.Methods: This explorato...

PURPOSE To investigate the profile of T-helper type 17 (Th17) cell-related cytokines (interleukin-23 [IL-23], IL-27, IL-17 and interferon-γ [IFN-γ]) in postoperative inflammation in patients with Behcet disease (BD) after cataract surgery. METHODS Serum was collected from seven BD patients with complicated cataract, and from nine controls with uncomplicated cataract, before cataract surgery, ...

Background: It has been established that the level of some inflammatory cytokines increases in celiac disease (CD) and non-celiac gluten sensitivity (NCGS) in comparison with healthy subjects. Therefore, the primary interest in our research was proposing an accurate tool to diagnose patients with CD and NCGS from healthy individuals in an Iranian population. Methods: The serum samples were exam...