Langerhans cells (LC), the dendritic cells of the epidermis, are distributed in a distinctive regularly spaced array. In the mouse, the LC array is established in the first few days of life from proliferating local precursors, but the regulating signaling pathways are not fully understood. We found that mice lacking the kinase phosphoinositide-dependent kinase 1 selectively lack LC. Deletion of...

Lung cancer (LC) is the most prevalent cancer worldwide, and responsible for over 1.3 million deaths each year. Currently, LC has a low five year survival rates relative to other cancers, and thus, novel methods to screen for and diagnose malignancies are necessary to improve patient outcomes. Here, we report on a pilot-sized study to evaluate the potential of the sputum microbiome as a source ...

PURPOSE To compare the visibility of the lamina cribrosa (LC) in optic disc images acquired from 60 glaucoma and 60 control subjects using three optical coherence tomography (OCT) devices, with and without enhanced depth imaging (EDI) and adaptive compensation (AC). METHODS A horizontal B-scan was acquired through the center of the disc using two spectral-domain (Spectralis and Cirrus; with a...

the aim of this study was to introduce modified continuous wave compaction (mcwc) technique and compare its obturation quality with that of lateral compaction (lc), warm vertical compaction (wvc) and continuous wave compaction techniques (cwc). the obturation time was also compared among the four techniques.sixty-four single-rooted teeth with 0-5° root canal curve and 64 artificially created ro...

AIM To assessed the effect of liver cirrhosis (LC) on the poorly understood long-term mortality risk after first-ever mechanical ventilation (1-MV) for acute respiratory failure. METHODS All patients in Taiwan given a 1-MV between 1997 and 2013 were identified in Taiwan's Longitudinal Health Insurance Database 2000. Each patient with LC was individually matched, using a propensity-score metho...

There is a need for decision-makers to be provided with both an overview of existing knowledge, and information which is as complete and up-to-date as possible on changes in certain features of the biosphere. Another objective is to bring together all the many attempts which have been made over the years at various levels (international, Community, national and regional) to obtain more informat...

The applications for the LMX2240 IF Receiver are discussed. Practical limitations of high frequency IF demodulators are examined, and methods to cope with these limitations are introduced. Specifically, methods to reduce the susceptibility to oscillation are given, and include layout considerations as well as circuit implementations. In addition, the demodulator tank circuit is examined in deta...