Previously, we isolated a novel gene, drs, which was downregulated by retroviral oncogenes such as v-src and v-K-ras, from a cDNA library of primary rat embryo fibroblasts. Experiments using a temperature-sensitive mutant of the v-src gene indicated that downregulation of drs mRNA was dependent on functional expression of v-Src. In addition, expression of drs mRNA was also reduced by serum stim...

BACKGROUND Inflammation and oxidative stress (OxS) contribute to the pathogenesis of diabetic kidney disease (DKD) and contrast-induced nephropathy (CIN). Patients with DKD were found to be more prone to CIN. Interleukin-33 (IL-33) is a proinflammatory cytokine, but its role in DKD and CIN is unknown. METHODS Thirty male Sprague-Dawley rats were enrolled. The first group was comprised of heal...

purpose: to report clinical features, types, and results of surgery for duane’s retraction syndrome (drs). methods: this is an existing data study on the records of patients with drs. the study was conducted on the hospital records of patients who were referred for drs to a tertiacy eye center in tehran, iran during 8 years. the follow-up period after the surgery was at least 6 months. results:...

Online and stochastic learning has emerged as powerful tool in large scale optimization. In this work, we generalize the Douglas-Rachford splitting (DRs) method for minimizing composite functions to online and stochastic settings (to our best knowledge this is the first time DRs been generalized to sequential version). We first establish an O(1/ √ T ) regret bound for batch DRs method. Then we ...

Duane retraction syndrome (DRS) is a congenital eye-movement disorder defined by limited outward gaze and retraction of the eye on attempted inward gaze. Here, we report on three heterozygous loss-of-function MAFB mutations causing DRS and a dominant-negative MAFB mutation causing DRS and deafness. Using genotype-phenotype correlations in humans and Mafb-knockout mice, we propose a threshold mo...