نتایج جستجو برای: ژن fabp4
تعداد نتایج: 16467 فیلتر نتایج به سال:
BACKGROUND Identifying beneficial surrogate genetic markers in psychiatric disorders is crucial but challenging. METHODS Given that scalp hair follicles are easily accessible and, like the brain, are derived from the ectoderm, expressions of messenger RNA (mRNA) and microRNA in the organ were examined between schizophrenia (n for first/second = 52/42) and control subjects (n = 62/55) in two s...
RATIONALE Apoptosis and fatty acid-binding protein-4 (FABP4) induced-endoplasmic reticulum (ER) stress in macrophage is an important pathological process in several vascular occlusive diseases, including atherosclerosis, both of which are accelerated by lipids or inflammatory cytokines. OBJECTIVE To determine whether interleukin 17A (IL-17A) accelerates atherosclerosis through activating FABP...
Over the last two decades, genetic lineage tracing has allowed for the elucidation of the cellular origins and fates during both embryogenesis and in pathological settings in adults. Recent lineage tracing studies using Apln-CreER tool indicated that a large number of post-natal coronary vessels do not form from pre-existing vessels. Instead, they form de novo after birth, which represents a co...
The fatty acid binding protein 4 (FABP4) plays an important role in the regulation of lipid metabolism in mammals. In this study, two regions of ovine FABP4 spanning exon 2-intron 2 and exon 3-intron 3 were investigated in four hundred and twenty lambs derived from seven sires that were previously typed as having heterozygous genotypes in both these regions of the gene. These regions have been ...
The increased incidence of obesity and metabolic disease underscores the importance of elucidating the biology of adipose tissue development. The recent discovery of cell surface markers for prospective identification of adipose precursor cells (APCs) in vivo will greatly facilitate these studies, yet tools for specifically targeting these cells in vivo have not been identified. Here, we survey...
Adipogenesis is regulated by a complex cascade of transcriptional factors, but little is known about the early events that regulate the adipogenic program. Here, we report the role of the srebf1a gene in the differentiation of fibroblastic 3T3-F442A cells. We found that expression of srebf1a depended on GSK3β activity and that GSK3β activity was necessary for C/EBPβ phosphorylation at Thr188. K...
این آزمایش به‌منظور بررسی و شناسایی همریخت (ایزوفرم)های RNA مرتبط با ساختار پروتئین‌های ماهیچه‌ای بین مرغ بومی اصفهان و جوجۀ تجاری راس با سرعت رشدهای متفاوت، انجام شد. بدین منظور و پس از استخراج کل RNA از نمونه‌های ماهیچۀ سینۀ مرغان یادشده در سن 28 روزگی، توالی‌یابی جفتی با استفاده از پلاتفرم illumine Hiseq 2000 انجام شد. برای همترازی خوانش‌ها به ژنگان (ژنوم) مرجع مرغ اهلی، از نرم‌افزار Hisat2...
INTRODUCTION Human immunodeficiency virus (HIV)-infected individuals are at a higher risk of developing metabolic disturbances. The pathogenesis of these complications is complex and not fully explored. OBJECTIVES The aim of the study was to investigate the effect of HIV infection and antiretroviral (ARV) therapy on the development of metabolic changes and adipocytokine concentrations. The an...
پروتئین متصل شونده به اسیدچرب (fabp) یک خانواده چند ژنی هستند که با برداشت، اکسیداسیون اسیدهای چرب و هموستازی متابولیک عمومی مرتبط می باشند. هدف از مطالعه حاضر شناخت چندشکلی ناحیه پروموتر و اگزون اول ژن fabp4 و ارتباط آن با صفات چربی و لاشه گوسفند بود. در این مطالعه 97 رأس بره نر آمیخته افشاری×برولا مرینو (نسل r1) با سن تقریباً یکسان از گله تحقیقاتی-آموزشی دانشگاه زنجان مورد استفاده قرار گرفتند....
The cellular mechanisms whereby excess maternal nutrition during pregnancy increases adiposity of the offspring are not well understood. However, nicotinamide (NAM), a fundamental micronutrient that is important in energy metabolism, has been shown to regulate adipogenesis through inhibition of SIRT1. Here we tested three novel hypotheses: 1) NAM increases the adipogenic response of human umbil...
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