Unsafe use of alcohol results in approximately 2.5 million deaths worldwide, with cirrhosis contributing to 16.6% of reported deaths. Serum insulin levels are often elevated in alcoholism and may result in diabetes, which is why alcoholic liver disease and diabetes often are present together. Because there is a sizable population with these diseases alone or in combination, the purpose of this ...

Background Over the last 20 years, the prevalence of hepatitis B virus (HBV) infection in China has decreased gradually due to the application of a national HBV vaccination program. In contrast, the prevalence of alcoholic liver disease (ALD), nonalcoholic fatty liver disease, autoimmune liver disease, and drug-induced liver injury has markedly increased. Methods We conducted a retrospective ...

The problems among obesity, diabetes mellitus (DM), fatty liver, metabolic dysfunction have been prevalent, and diagnostic criteria as non-alcoholic liver disease (NAFLD) has used in practice. When diagnosing NAFLD, to exclude other related diseases was necessary, including excessive alcohol intake. international experts proposed the proper term from NAFLD associated (MAFLD). MAFLD include evid...

Although altered cytokine homeostasis has been implicated in the pathogenesis of both alcoholic liver and pancreas diseases, the serum cytokine pattern characteristic of concomitant alcoholic liver cirrhosis and pancreatitis has not been examined. In this paper we examine the serum levels of proinflammatory cytokines, such as IL-6, IL-8, TNF-alpha, and also antiinflammatory ones, such as IL-10 ...

Background: The world is now in the process of passing on health to non-diseases chronic, like non-alcoholic fatty liver (NAFLD) is a major cause of changes in the lifestyle of people. This study aims to evaluate the effects of lifestyle on fatty liver disease (NAFLD). Methods: For this critical review, we identified articles by searching original studies and review articles published in peer ...

The aim of the review is to highlight main factors affecting development liver fibrosis and possible mechanisms damage in patients who have experienced COVID-19. A search was carried out using keywords Scopus, Web Science, PubMed databases literary sources last three years on associated with fibrogenesis novel coronavirus infection. presents COVID-19: direct effects hepatocytes cholangiocytes, ...

Endoplasmic reticulum (ER) is the major site of protein folding and calcium storage. Beside the role of ER in protein homeostasis, it controls the cholesterol production and lipid-membrane biosynthesis as well as surviving and cell death signaling mechanisms in the cell. It is well-documented that elevated plasma cholesterol induces adverse effects in cardiovascular diseases (CVDs), liver disor...