Background: The aim of the study was to determine mechanism Moringa oleifera-induced apoptosis in HeLa cells. cells over-express cyclin E and B1, abrogate G0-G1 G2-M cell cycle arrest, promoting tumorigenesis. Cyclin E, E2F1 telomerase expression, caspase-3 -7 activation were assessed after 24-treatment with M. oleifera leaf fractions. Material methods: Apoptosis through caspase-7 determined qu...

Abstract Background Cervical cancer remains a significant global health issue, highlighting the need for effective therapeutic strategies. Given that Sphaerocoryne affinis (SA) has shown potential anti-cancer activity in several types, herein, we investigate effects of SA fruit (SAF) on human cervical HeLa cells and their underlying mechanisms action. Methods SAF extract cytotoxicity was assess...

biodegradable polymeric nanoparticles (nps) have been intensively studied as a possible way to enhance anti-tumor efficacy while reducing side effects. icd-85, derived from the venom of two separate species of venomous animals, has been shown to exhibit anti-cancer activity. in this report polymer based sodium alginate nanoparticles of icd-85 was used to enhance its therapeutic effects and redu...

Thyroid cancer (TC) is the most prevalent malignant tumor in endocrine system. Serpin peptidase inhibitor clade E member 2 (SERPINE2) closely associated with metastasis. The aim of present study was to investigate whether SERPINE2 forms a feedback loop epidermal growth factor (EGF)/EGF receptor (EGFR) that regulates cellular processes human papillary thyroid carcinoma (TPC‑1) cells. Reverse tra...

Abstract Background Combination chemo-photothermal therapy appears to be one of the next generations cancer treatment. In this study hollow gold nanostars (HGNSs) and nanocages (GNCs) were synthesized stabilized with thermo-pH-sensitive thiol-end capped ABC triblock copolymer poly(acrylic acid)-b-poly( N isopropylacrylamide)-b-poly (e-caprolactone)-SH; PAA-b-PNIPAAm-b-PCL-SH (GNSs@Pol). Doxorub...

Background: Colorectal cancer (CRC) is attributed as one of the most common malignancies worldwide. CD133 molecule, as a pentaspan transmembrane glycoprotein, confers stem cell-related characteristics, including self-renewal and multi-directional differentiation capability. CD133 plays important roles in the progression of CRC by conferring apoptotic resistance and migration ab...

Background: It seems that Vinca. herbacea has an anti-tumor effect. Here, the immunotherapeutic effect of this compound is assessed against human ovarian cancer (SKOV3) cells because of the high incidence of this tumor in women. Materials and Methods: The cytotoxic activity of V. herbacea extract against human ovarian cancer (SKOV3) cells was determined by MTT assay. The apoptosis-inducing pote...

Background and Aims: Natural compounds derived from animal, plant, and microbial sources participate in treating various types of cancers, including lung cancer. This survey attempted to explore the anticancer activity of two novel metabolites extracted from soil-derived actinomycetes in the human lung cancer A549 cells. Materials and Methods: The crude extracts of UTMC 638 and UTMC 877 second...

Objective(s): Juglone is isolated from many species of the Juglandaceae family and used as an anti-viral, anti-bacterial, and anti-tumor therapeutic. Here, we evaluated juglone-induced antitumor effect in ovarian cancer SKOV3 cells. Materials and Methods: MTT assay was performed to examine juglone anti-proliferative effect. Cell cycle and apoptosis were studied using flow cytometry in juglone-t...

Background: Cytosolic double-stranded RNA (dsRNA) is an important ‘molecular signature’ for the detection of intracellular viral infections. Although intracellular dsRNA is a known potent inducer of apoptosis, the optimal time and dose for the onset of dsRNA-mediated apoptosis have not been studied in detail. Objective: To perform an accurate temporal assessment of the cell death responses in d...