نتایج جستجو برای: apoptotic effect
تعداد نتایج: 1679148 فیلتر نتایج به سال:
objective(s): the aim of this study was to determine the important molecules involved in apoptosis induction by opium in jurkat cell line. materials and methods: jurkat cells were incubated 48 hrs with2.86×10-5 g/ml concentration of opium and apoptosis as well as expression levels of related molecules weremeasured. results: our results demonstrated that 50.3±0.2 percent of opium treated jurkat ...
Lithium (Li) is still useful in the treatment of bipolar disorder. Cellular mechanisms of Li action are not fully understood and include some cytoprotective properties. Data concerning Li effect on the apoptotic mechanisms in cells other than neurons are fragmentary and contradictory. We have investigated anti-apoptotic activity of Li in a lymphoid derived MOLT-4 cell line. Spontaneous and camp...
Background and Objective: Proliferation and apoptosis of lymphocytes are essential parts of the immune system. Most anti-cancer chemotherapy drugs such as vincristine target cell cycle and induce apoptosis in cancer cells. In other words, dividing cells undergo more apoptosis, which may also include the normal proliferating lymphocytes responsive to malignancies as well. Materials ...
Introduction: Parkinson disease (PD) is the second most common neurodegenerative disease affecting older individuals with signs of motor disability and cognitive impairment. Epicatechin (EC) and edaravone have neuroprotective effects most probably due to their antioxidant activity; however, a limited number of studies have considered their role in PD. This research aimed at investigating the ne...
Objective: Some previous studies have shown that protective effect of caffeine against induction of apoptosis through in the regulation of pro- and anti-apoptotic proteins. Therefore, the aim of this study was to investigate the effects of chronic caffeine administration on the interactions among of Bax and Bcl-2 proteins in the cardiac tissue of induced type two diabetic rats. Methods: In exp...
Introduction: Today, obesity is one of the main public health problems worldwide due to the increased risk of cancer in obese people and the role of apoptosis in preventing diseases such as cancer. Therefore, the aim of this study was to investigate the effect of cannabis on the expression of Bax and Bcl-2 apoptotic genes in adipose tissue cells. Methods: In this experimental study, 32 adult ma...
objective: perovskia abrotanoides karel, belongs to the family lamiaceae and grows wild alongside the mountainous roads inarid and cold climate of northern iran. the anti-tumor activity of p. abrotanoides root extract has been shown previously. this study was designed to examine in vitro anti-proliferative and pro-apoptotic effects of flower extract of p. abrotanoides on mcf-7 and hela cell lin...
The antioxidant alpha-lipoic acid (LA) is a naturally occurring compound that has been shown to possess promising anticancer activity because of its ability to preferentially induce apoptosis and inhibit proliferation of cancer cells relative to normal cells. However, the molecular mechanisms underlying the apoptotic effect of LA are not well understood. We report here that LA induced reactive ...
This study investigated the cytotoxic effect of uvangoletin on HL-60 cells, and the effects of uvangoletin on myelosuppression, leucopenia, gastrointestinal tract disturbances and the possible cytotoxic mechanisms by using CCK-8, flow cytometry, western blot, xenograft, cyclophosphamide-induced leucopenia, copper sulfate-induced emesis and ethanol-induced gastric mucosal lesions assays. The res...
the purpose of the present study is to investigate the cytotoxicity/apoptotic effect of 2-chloro-2′-deoxyadenosine, cladribine, (2-cda) in the human breast cancer cell line, mda-mb468 (estrogen receptor negative, er−). mtt [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2h tetrazolium bromide] assay, annexin v-fluorescein/pi and hoechst 33258 staining were used to detect cytotoxicity and cell apopto...
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