MOTIVATION The Hi-C technology was designed to decode the three-dimensional conformation of the genome. Despite progress towards more and more accurate contact maps, several systematic biases have been demonstrated to affect the resulting data matrix. Here we report a new source of bias that can arise in tumor Hi-C data, which is related to the copy number of genomic DNA. To address this bias, ...

BACKGROUND The objective of this study was to demonstrate the use of the Heckman two-step method to assess and correct for bias due to missing health related quality of life (HRQL) surveys in a clinical study of acute coronary syndrome (ACS) patients. METHODS We analyzed data from 2,733 veterans with a confirmed diagnosis of acute coronary syndromes (ACS), including either acute myocardial in...

We consider the effect of reionization on the clustering properties of galaxy samples at intermediate redshifts (z ∼ 0.3–5.5). Current models for the reionization of intergalactic hydrogen predict that overdense regions will be reionized early, thus delaying the build up of stellar mass in the progenitors of massive lower-redshift galaxies. As a result, the stellar populations observed in inter...

Introduction Evaluation of the delivered dose of externally wedged photon beams by external diode dosimeters during the treatment process requires the estimation of exit surface dose correction factors in various wedge angles and field sizes. Materials and Methods A system of absorbed dose evaluation, using p-type diode dosimeters placed on the exit surface of a phantom, was characterized for e...

General purpose gamma scanners are often used to assay unknown drums that differ from those used to create the default calibration. This introduces a potential source of bias into the matrix correction when the correction is based on the estimation of the mean density of the drum contents from a weigh scale measurement. In this paper we evaluate the magnitude of this bias that may be introduced...

This paper studies fixed effects estimation of quantile regression (QR) models with panel data. Previous studies show that there are two important difficulties with the standard QR estimation. First, the estimator can be biased because of the well-known incidental parameters problem. Secondly, the non-smoothness of the objective function significantly complicates the asymptotic analysis of the ...

We investigate the effect of primordial non-Gaussianity of the local fNL type on the autoand cross-power spectrum of dark matter haloes using simulations of the ΛCDM cosmology. We perform a series of large N-body simulations of both positive and negative fNL, spanning the range between 10 and 100. Theoretical models predict a scale-dependent bias correction ∆b(k, fNL) that depends on the linear...

A very serious concern of scientists dealing with crystal structure refinement, including theoretical research, pertains to the characteristic bias in calculated versus measured diffraction intensities, observed particularly in the weak reflection regime. This bias is here attributed to corrective factors for phonons and, even more distinctly, phasons, and credible proof supporting this assumpt...

Background: Estimating dosimetric parameters for small fields under non-reference conditions leads to significant errors if done based on conventional protocols used for large fields in reference conditions. Hence, further correction factors have been introduced to take into account the influence of spectral quality changes when various detectors are used in non-reference conditions at differen...