This study examined the effect of the cross-linking with riboflavin-ultraviolet A (UVA) irradiation on the chemical bonds and ultrastructural changes of human sclera tissues using Raman spectroscopy and atomic force microscopy (AFM). Raman spectroscopy of the normal and cross-linked human sclera tissue revealed different types of the riboflavin-UVA and collagen interactions, which could be iden...

The authors compared porcine corneal and scleral membrane phospholipids determined with use of 31P nuclear magnetic resonance (NMR). These tissues make up the tunica fibrosa (outer coat) of the eye. Since the sclera, unlike the cornea, does not possess an epithelium or an endothelium, comparative analysis of these tissues included examination of the cornea with and without its epithelium and en...

OBJECTIVE To evaluate the effect of blocking the angiotensin II AT-1 receptor by the systemic administration of candesartan on the expression of intercellular adhesion molecule-1 in the sclera and choroid of hypercholesterolemic rabbits. METHODS New Zealand rabbits were divided into 3 groups, as follows: GI, which was fed a rabbit standard diet; GII, which was fed a hypercholesterolemic diet;...

OBJECTIVE To analyze the expression and cellular distribution of intercellular adhesion molecule 1, E-selectin (endothelial leukocyte adhesion molecule), vascular cell adhesion molecule 1, very late antigen 4, and lymphocyte function associated antigen 1 (LFA-1) in diseased and normal human sclera. METHODS Monoclonal antibodies to vascular cell adhesion molecule 1, very late antigen 4, interc...

Nevus of Ota is a condition wherein the typical pattern of the bluish black pigmentation is noticed along with the cutaneous distribution of the trigeminal nerve. This condition is most prevalent in Japanese population but comparatively rare among Indians. We report a case of 23-year-old female presented with unilateral pigmented areas over the skin of forehead, malar area, ear and periorbital ...

A 15-year-old girl with osteogenesis imperfecta (OI) and multiple bone fractures since early childhood presented with occipital headache. She had blue sclera and short neck (figure 1), right hypoglossal palsy, bilateral pyramidal tract signs, and gazeevoked nystagmus. Cervical MRI showed platybasia, basilar invagination, brainstem/high cord compression, and narrowing of upper cervical canal (fi...

E10 CUTIS WWW.CUTIS.COM To the Editor: Nevus of Ota, also known as oculodermal melanocytosis or nevus fuscoceruleus ophthalmomaxillaris, is a hamartoma of dermal melanocytes that is characterized by a unilateral or bilateral blue-brown, speckled patch usually involving the malar, periorbital, temple, and/or forehead regions of the face.1 It also may affect the sclera, conjunctiva, retinas, corn...