Objective(s): Previous studies have indicated that phytoestrogens induce estrogenic as well as anti-inflammatory effects, and they are found in high abundance in the extracts of some herbs such as Vitex Agnus Castus (VAC). Therefore, we investigated the effect of VAC extract on ovariectomized mice after the induction of permanent middle cerebral artery occlusion (PMCAO...

We sought to characterize the relationship between integrity of the white matter underlying the ventral anterior cingulate (vAC) and depressive symptoms in older adults with atherosclerotic vascular disease (AVD), a condition associated with preferential degeneration of the white matter. The vAC was defined as including white matter underlying ventral Brodmann Area 24 and Brodmann Area 25, corr...

I read with great interest the paper by Yu et al. in which they compare outcomes of vacuum-assisted closure (VAC) therapy with conventional management in patients with post-sternotomy mediastinitis (PSM) [1]. There is no general consensus concerning the appropriate surgical approach to PSM and multiple wound healing strategies have been proposed [2]. The treatment of PSM has changed radically w...

BACKGROUND Regenerative surgery deals with damaged tissue via endogenous cell activation or through autologous cell implantation. Several clinical applications employing cell infusions, platelet gel (PG), or both, are currently applied in cases in which no other therapy is application. The vacuum-assisted closure (VAC) system is a non invasive device used in the management of complicated wounds...

Dear Editors, Vacuum-assisted closure (VAC) devices provide negative pressure wound therapy (NPWT), and are currently employed frequently in the management of complex wounds. NPWT has been shown to improve clinical outcomes significantly. Proposed mechanisms of action for this wound management system include providing strain, which promotes more rapid wound closure by encouraging perfusion, fib...

Surgery in patients with hepatic cirrhosis and ascites is associated with significant morbidity, including poor wound healing. Postoperative management of abdominal and perineal wounds in these patients poses a unique challenge owing to increased intra-abdominal pressure, risk for peritonitis, and ascitic fluid leakage. Vacuum-assisted closure (VAC) therapy reportedly improves angiogenesis and ...

BACKGROUND Mechanical forces play an important role in tissue neovascularization and are a constituent part of modern wound therapies. The mechanisms by which vacuum assisted closure (VAC) modulates wound angiogenesis are still largely unknown. OBJECTIVE To investigate how VAC treatment affects wound hypoxia and related profiles of angiogenic factors as well as to identify the anatomical char...

BACKGROUND The vacuum assisted closure (VAC) therapy has revolutionized the modern wound care. We developed a new concept of 'VAC at home' in order to decrease the hospital cost. METHODS The study was conducted in a private hospital from January 2009 to December 2010. Only those patients were included among whom the wounds were not complicated by concomitant injury and the patients were other...

Postoperative deep sternal wound infection (DSWI) is a serious complication in cardiac surgery (1-5% of patients) with high mortality and morbidity rates. Vacuum-assisted closure (VAC) therapy has shown promising results in terms of wound healing process, postoperative hospital length of stay and lower in-hospital costs. The aim of our retrospective study is to report the outcome of patients wi...