Objective(s):Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. One of the hallmarks of AD is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. In this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in AD and tauopathies. Unfortunately, the available syntheti...

Objective(s) Anti-Helicobacter pylori effects of saffron (Crocus sativus L., Iridacea) and its major constituents, crocin and safranal, were evaluated. Materials and Methods Macerated aqueous and methanol extracts tested against 45 clinical isolates of Helicobacter pylori, using paper disc diffusion method (DDM) on modified egg yolk emulsion agar (EYE agar). Four antibiotics also tested agai...

objective: crocin, the carotenoid isolated from saffron, has numerous medicinal properties which include anticancer and antioxidant activities. some antioxidants, such as carotenoids, can act as pro-oxidants at higher dosages and therefore induce tissue damage. in this situation antioxidant defense systems in the liver activate to prevent tissue damage. this study investigates the possible toxi...

saffron (crocus sativus l.), the most valuable medicinal food product, belongs to the iridaceae family, which has been widely used as a coloring and flavoring agent. the stigmas contain three major compounds; crocins (carotenoid compound responsible for color), picrocrocin (responsible for taste) and safranal (responsible for odor). it has been used for medicinal purposes, as a spice and condim...

Crocus sativus is a triploid sterile plant with red stigmas belonging to family of Iridaceae, and sub Crocoideae. Crocin, picrocrocin, safranal are three major carotenoid derivatives that responsible for color, taste specific aroma Crocus. Saffron flowers harvested manually used as spice, dye or medicinal applications. The natural propagation rate most geophytes including saffron relatively low...

Saffron, the dried red-orange stigmas of Crocus sativus L, has been known as a flavoring agent, food coloring and traditional herbal medicine. Pharmacological effects of saffron are mainly attributed to crocin, crocetin, picrocrocin and safranal. These components especially crocin, have significant effects including antidepressant and anticonvulsant, analgesic, anti-cancer and other therapeutic...

objectives: crocin, a constituent of saffron and yellow gardenia, possesses anti-nociceptive effects. in the present study, we investigated the effects of intra-fourth ventricle injection of crocin in a rat model of orofacial pain. the contribution of opioid system was assessed using intra-fourth ventricle injection of naloxone, an opioid receptor antagonist. materials and methods: a guide cann...

saffron, the dried red-orange stigmas of crocus sativus l, has been known as a flavoring agent, food coloring and traditional herbal medicine. pharmacological effects of saffron are mainly attributed to crocin, crocetin, picrocrocin and safranal. these components especially crocin, have significant effects including antidepressant and anticonvulsant, analgesic, anti-cancer and other therapeutic...

the substances responsible for saffron’s characteristic quality are crocins, picrocrocin, and safranal. the drying process is critical to the saffron quality as measured by levels of secondary metabolites, crocin (color and anti-tumor properties), picrocrocin (taste), and safranal (aroma). four different dehydration methods were evaluated: iranian traditional method (room temperature); dehydrat...