the early stages of liver carcinoma development in Sprague-Dawley rats. Bile acids were analyzed in urine and feces of azo dye-fed and control rats with the use of gas chromatography during the first 66 days of treatment. Seven bile acids were identified in the feces, with deoxycholic acid being the primary excretion product. During the first 36 days of 3'-methyl-4-dimethylaminoazobenzene feedi...

AIMS In this study, we tested the impact of pretreatment with alcohol on subsequent alcohol drinking in outbred Sprague-Dawley and selectively bred alcohol-preferring (P) rats. METHODS As a pretreatment, male Sprague-Dawley and P rats were given a passive oral administration of either alcohol (1.0 g/kg) or tap water. Then, they were given free choice of drinking alcohol (5% v/v) or water in t...

background: urinary tract infection in children may cause renal scar formation, which can be prevented by early and appropriate treatment. recent studies showed that single daily injection of gentamycin can produce best effect without increasing the side effects. the aim of this study was to evaluate the rate of renal scar formation when new regime (every other day gentamicin injection) used fo...

In Sprague-Dawley rats, fatty acid synthase (FAS) activity is suppressed by dietary fat. To test the hypothesis that a defect in regulation of de novo fatty acid synthesis exists in massive obesity, we investigated the effect of diet on FAS mRNA levels in genetically obese JCR:LA-corpulent (cp) rats. We also determined levels of mRNA encoding adipsin, a fat cell-derived protein possibly associa...

Evans, S. A., M. M. Messina, W. D. Knight, A. D. Parsons, and J. M. Overton. Long-Evans and Sprague-Dawley rats exhibit divergent responses to refeeding after caloric restriction. Am J Physiol Regul Integr Comp Physiol 288: R1468–R1476, 2005. First published February 3, 2005; doi:10.1152/ajpregu.00602.2004.—Mature male Sprague-Dawley (SD) and Long-Evans (LE) rats were instrumented with telemetr...

Objective(s):The present study investigated the effect of long-term mild cerebral hypoperfusion induced by permanent unilateral (right) common carotid artery occlusion (UCO) on the dorsal hippocampal neurons in rats. Materials and Methods:Sixty four male Sprague-Dawley rats aged 4 months were divided into two groups of sham and UCO. These two groups were further divided into 4 sets of histopath...

Lignosus rhinocerotis (Cooke) Ryvarden (LR) or tiger milk mushroom has traditionally been used in Malaysia due to its abundant medicinal properties. The potential effects of LR on the male and female fertility teratogenicity were investigated rats. Male Sprague Dawley (10 rats/group) orally administered with 0, 250, 500 1000 mg/kg/day extract for 30 consecutive days. Female (5 received same tre...

Purpose: To determine the anti-scarring effect of polysulfonic acid mucopolysaccharide (MSP), and implication TGF-β1/Smad signal transduction route.Methods: Sixty (60) male Sprague Dawley (SD) rats were assigned to control, model groups, respectively, each with 20 rats. Serum inflammatory factors, scar area thickness, histopathological changes relative concentrations TGF-β1 Smad4, collagen type...