Whole Exome Sequencing (WES) has been increasingly utilized in genetic determinants of various inherited diseases. We identified a new variation in SERAC1 as the cause of 3-Methylglutaconic Aciduria (MEG), Deafness (D), Encephalopathy (E), and Leigh-like (L), MEGDEL syndrome using WES. We found an insertion, rs797045105 (chr6, 158571484, C>CCATG), in the SERAC1 gene with homozygous genotype in ...

Seven microsatellite loci were used to develop multilocus genotypes for 49 individuals of Neotoma stephensi (Stephen’s woodrat) collected from nine sites in central and northern Arizona. Several statistical analyses were used to determine genetic structure, levels of genetic variability, and degree of relatedness. Structure analyses estimated two distinct groups within localities. The FST value...

Research has shown that prosocial behaviors of various kinds are passed from generation to generation, but the role played by genetics in the transmission of volunteerism has been unexplored. Data from the Midlife in the United States (MIDUS) Twins and Siblings samples are used to estimate genetic heritability of hours volunteered per month. Although unique environmental factors of the kind soc...

Welcome to this special issue of PPAR Research dedicated to the “Genetic Variation of PPARs.” Since PPARs are nuclear transcription factors regulating multiple genes involved in energy production, glucose and lipid metabolism, polymorphisms in these receptors may influence the pathology of numerous diseases including obesity, diabetes, atherosclerosis, inflammation and cancer. The first section...

Until recently, it was impracticable to identify the genes that are responsible for variation in continuous traits, or to directly observe the effects of their different alleles. Now, the abundance of genetic markers has made it possible to identify quantitative trait loci (QTL)--the regions of a chromosome or, ideally, individual sequence variants that are responsible for trait variation. What...

What is cryptic genetic variation? Cryptic genetic variation refers to unexpressed, bottled-up genetic potential. It is not normally seen, but is expressed under abnormal conditions such as in a new environment or a different genetic background. In a sense, the measurable component of normal variation is just the tip of an iceberg of genetic possibilities that are hidden below the visible surface.

safflower is an oilseed crop with high adaptability to rainfed conditions of iran. it is native crop in iran and due to some morphological characters specially root system it shows good resistance to drought stress. in present investigation to study genetic variation in fall planting of safflower in rainfed condition 100 genotypes were evaluated in a 10×10 simple lattice square design with two ...

Genetic diversity amongst 21 induced mutant clones tolerant to salinity along with one non-irradiated sensitive clone of banana (Musa acuminata cv. Dwarf Cavendish (AAA)) were studied using morphological and random amplified polymorphic DNA (RAPD) markers. Out of the 30 phenotypic indices screened, 23 were polymorph and two traits, leaf habit and blotches color, were differentiated by non-irrad...