The purpose of this work was to study the effect of various permeation enhancers on the permeation of salbutamol sulphate (SS) buccal patches through buccal mucosa in order to improve the bioavailability by avoiding the first pass metabolism in the liver and possibly in the gut wall and also achieve a better therapeutic effect. The influence of various permeation enhancers, such as dimethyl sul...

Purpose: To utilize hydroxybutyl-β-cyclodextrin (HB-β-CD) and polyvinyl pyrrolidone (PVP) for the enhancement of the transdermal delivery of glimepiride (GMD). Methods: Matrix-type transdermal patches containing GMD, drug coprecipitate or its inclusion complex were prepared using different gelling agents, viz, hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), carbopol and chi...

PURPOSE To investigate the suitability of an SCMC (sodium carboxymethyl cellulose/polyethylene glycol 400/carbopol 934P) and an HPMC (hydroxypropylmethyl cellulose/polyethylene glycol 400/carbopol 934P) films as drug vehicle for buccal delivery. METHODS The mechanical and in vitro bioadhesive strength properties of the films were investigated using texture analyzer equipment, while swelling b...

During the dissolution of cocrystal particles, solution-mediated phase transformation (SMPT) can occur either on particle surface (PS-SMPT) or in bulk solution (BP-SMPT). In this study, we compared effect various polymers PS-SMPT and BP-SMPT for first time using carbamazepine saccharine (CBZ-SAC) as a model drug. Polyethylene glycol 6000 (PEG), polyvinylpyrrolidone K-30 (PVP), hydroxypropyl met...

Antimicrobial activity and the properties of edible film were studied by incorporating with encapsulated clove (Eugenia caryophyllata Thunb.) oil as a natural antibacterial agent. The minimal bactericidal concentration (MBC) of clove oil inhibited the growth of E. coli O175:H7, S. aureus and L. monocytogenes were tested in the stationary phase. The results showed that 1.0, 1.5 and 0.5% of clove...

A solid biopolymer electrolytes (BEs) based on hydroxypropyl methylcellulose (HPMC) doped with different concentrations of ceric ammonium nitrate (NH4)2Ce(NO3)6 (CAN) were prepared by solution cast method. Different techniques has been employed to investigate the effects of structural, thermal and ionic conductivity behavior of these polymer electrolyte films upon gamma irradiation with differe...

treatment, biologically. Levobunolol HCl occuserts were prepared using hydroxypropyl methylcellulose (HPMC, 3% & 4%), poly vinyl pyrrolidone (PVP, 1%), methyl cellulose (MC, 1% & 2%) as polymers by solvent casting technique with objectives of increasing contact time, achieving controlled release, reduction in frequency of administration and greater therapeutic efficacy. Based on their physioche...