Malaysian sea cucumber was incorporated into hydrogel formulation by using electron beam irradiation technique and was introduced as novel cross-linked Gamat Hydrogel dressing. This study investigated whether Gamat Hydrogel enhanced repair of deep partial skin thickness burn wound in rats and its possible mechanism. Wounds were treated with either Gamat Hydrogel, control hydrogel, OpSite® film ...

The dynamics of fluid-borne superparamagnetic bead transport by field-driven domain walls (DWs) in submicrometer ferromagnetic tracks is studied experimentally together with numerical and analytical modeling. A combination of micromagnetic modeling and numerical calculation is used to determine the strength of bead-DW interaction for a range of track geometries and bead sizes. The maximum DW ve...

In the present study, textural and structural characterizations of chitosan bead for immobilization of alpha amylase were studied in detail by N2 adsorption–desorption, Microspore Analysis (MP), Barrett–Joyner–Halenda (BJH) plots and Field Emission Scanning Electron Microscope (FESEM) observations. Pore structure observation revealed chemical activation of chitosan bead by glutaralde...

Additive Manufacturing describes the technologies that can produce a physical model out of a computer model with a layer-by-layer production process. Additive Manufacturing technologies, as compared to traditional manufacturing methods, have the high capability of manufacturing the complex components using minimum energy and minimum consumption. These technologies have brought about the possibi...

Background—Hydrogels are being actively investigated for direct delivery of cells or bioactive molecules to the heart post-myocardial infarction (MI) to prevent cardiac functional loss. We postulate that immobilization of the pro-survival angiopoietin-1-derived peptide, QHREDGS, to a chitosan-collagen hydrogel could produce a clinically translatable thermo-responsive hydrogel to attenuate post-...

The objective of this study was to develop thin, biocompatible, and biofunctional hydrogel-coated small-sized nanoparticles that exhibit favorable stability, viability, and specific cellular uptake. This article reports the coating of magnetic iron oxide nanoparticles (MIONPs) with covalently cross-linked biofunctional polyethylene glycol (PEG) hydrogel. Silanized MIONPs were derivatized with e...

BACKGROUND Stringent control of proteolytic activity represents a major therapeutic approach for wound-bed preparation. OBJECTIVES We tested whether a protease-modulating polyacrylate- (PA-) containing hydrogel resulted in a more efficient wound-bed preparation of venous leg ulcers when compared to an amorphous hydrogel without known protease-modulating properties. METHODS Patients were ran...

The purpose of this study was to produce a novel pH sensitive hydrogel with superior thermal stability, composed of poly(acrylic acid) (PAA) and cellulose nanocrystal (CNC). CNC was extracted from kenaf fiber through a series of alkali and bleaching treatments followed by acid hydrolysis. PAA was then subjected to chemical cross-linking using the crosslinking agent (N,N-methylenebisacrylamide) ...

The diffusion and transport of substances between a hydrogel and its environment have received tremendous research interest, due to the wide range of applications of hydrogel materials in fields related to drug carriers and drug delivery vehicles. To date, much research has been done to tailor the diffusion and transport of substances through hydrogels, where most efforts were focused on tuning...

BACKGROUND Hydrogels are being actively investigated for direct delivery of cells or bioactive molecules to the heart after myocardial infarction (MI) to prevent cardiac functional loss. We postulate that immobilization of the prosurvival angiopoietin-1-derived peptide, QHREDGS, to a chitosan-collagen hydrogel could produce a clinically translatable thermoresponsive hydrogel to attenuate post-M...