Multiple sclerosis is an autoimmune disease of the central nervous system which its main characteristic is an inflammation and demyelination and subsequent, neural degeneration. Many studies have shown that inflammation causing neuronal demyelination. MS is the most common cause of chronic neurological disability in during youth which the prognosis is that can be death. Platelet activating fact...

Abstract Background IL-37 is an anti-inflammatory cytokine that increases in several inflammatory diseases with the main inducing signal for its production being pro-inflammatory cytokines like TNF-?. We aimed to assess correlation between peritoneal fluid levels of and TNF-? endometriosis patients investigate their association disease stage. Levels were assessed 50 23 endometriosis-free female...

introduction  insulin-like growth factor i (igf-i) which is produced in abundance in the normal adult liver, is deeply involved in hepatocyte survival, growth, and differentiation during liver development. igf-i plays the roles via the receptor (igf-ir) signaling pathway. igf-ir unlike igf-i is expressed strongly in the developing liver, but much more weakly in adults. objective:  we hypothesiz...

the physiologic function of the immune system is defense against infectious microbes and internal tumour cells, therefore, need to have precise modulatory mechanisms to maintain the body homeostasis. the mammalian cellular cd200 (ox2)/cd200r interaction is one of such modulatory mechanisms in which myeloid and lymphoid cells are regulated. cd200 and cd200r molecules are membrane proteins that t...

Purpose: To investigate the therapeutic role of diosmetin in periodontitis and its probable mechanism action.Methods: Lipopolysaccharide (LPS) was used to induce periodontal cells. Cell viability apoptosis response LPS were evaluated using MTT TUNEL assays. The oxidative stress inflammatory responses LPS-induced effects cells detected enzyme-linked immunosorbent assay (ELISA). In addition, role...

Curcumin, an active substance contained in Indian spice called turmeric or curcuma, is well known for its anti-inflammatory and antioxidant properties. In recent times, it was taken into account studied as antitumoral molecule, by relying on interference several biological mechanisms, such the inhibition of inflammatory mediators, enhancement detoxifying enzymes’ action processes cell growth pr...

Polycystic ovary syndrome (PCOS) is a low-grade inflammatory state with increased serum levels of TNFα. The present study has compared the inflammatory responses to breast cancer cell lines in women with PCOS with healthy women. Peripheral blood mononuclear cells (PBMCs) isolated from 50 women with PCOS and 50 healthy controls were cultured in the trans-well co-culture system. These cells were ...