Transplantation of neural stem cells (NSCs) offers a novel therapeutic strategy for stroke; however, massive grafted cell death following transplantation, possibly due to a hostile host brain environment, lessens the effectiveness of this approach. Here, we have investigated whether reprogramming NSCs with minocycline, a broadly used antibiotic also known to possess cytoprotective properties, e...

Objective: To explore the inflammatory mechanism that Obstructive Sleep Apnea Syndrome (OSAS) impacts ischemic stroke. Methods: 100 patients admitted in department of neurology of our hospital were enrolled in the study and assigned into the cerebral ischemic stroke group without OSAS (control group, n=50) and the cerebral ischemic stroke group with OSAS (observation group, n=50). whose Apnea H...

BACKGROUND AND PURPOSE Early identification of stroke patients at risk for fatal brain edema may be useful in selecting patients for aggressive interventions. Prior studies suggested that early nausea/vomiting and major hypodensity on baseline computed tomography (CT) were predictive of herniation. METHODS This study was a retrospective multicenter case-control study of patients with large mi...

Malignant cerebral edema following ischemic stroke is life threatening, as it can cause inadequate blood flow and perfusion leading to irreversible tissue hypoxia and metabolic crisis. Increased intracranial pressure and brain shift can cause herniation syndrome and finally brain death. Multiple randomized clinical trials have shown that preemptive decompressive hemicraniectomy effectively redu...

Background: The role of estrogen and progesterone in stroke is suggested in previous studies, but yet is controversial. Objectives: Comparing the plasma levels of estrogen and progesterone and their ratio in ischemic stroke patients and healthy population. Materials and Methods: This cross-sectional comparative study was conducted from March to September of 2013. Sixty-six female patients older...

Introduction: Stroke is known as a common cause of disability all over the world. Stroke prognosis estimation has always been a topic of interest. In this study, it was tried to investigate the prognostic value of laboratory findings of complete blood count in a systematic review. Methods: In this systematic review, literature from Medline via (PubMed, Ovid) Embase, Scopus, Cochrane Library, a...

thrombolysis for stroke is being used in some developing countries. this study was designed to evaluate the problems of thrombolysis therapy in iran. during january-july 2008, all patients with ischemic stroke admitted to ghaem hospital, mashhad, northeast iran, were enrolled in a prospective observational study. ghaem hospital is a tertiary care hospital that includes infrastructure for thromb...