Objective(s): Weight gain and metabolic disturbances such as dyslipidemia, are frequent side effects of second-generation antipsychotics, including olanzapine. This study examined the metabolic effects of chronic olanzapine exposure. In addition, we investigated the hepatic fatty acid effects of olanzapine in female C57BL/6J mice fed a normal diet.Materials and Methods: Female C57BL/6J mice ora...

Abstract The aim of this work is to evaluate the role Grape Seed extracts (GSE) from three grape cultivars (Ahmer, Halawani, and Kamali) grown in Iraq as well pomace on lipid profile diabetic mice. Fifty adult female mice were divided into five groups. Negative control (untreatment), positive (treated) diabetic, treated with GSE. After six weeks; serum liver tissue homogenate parameters evaluat...

BACKGROUND Methamphetamine (MA) is a potent psychomotor stimulant with high abuse and addictive potential. MA is a neurotoxic drug which is widely abused by females of childbearing age, raising serious public health concerns in terms of exposure of the fetus to the drug. Neurotoxic effects of MA on adult are well known, such as dopaminergic nerve terminal degeneration and cell death in regions ...

background: this study was carried out to observe the radioprotective effects of rosemarinus officinalis leaves extract (roe) against radiation-induced histopathological alterations in liver of mice. materials and methods: adult swiss albino mice were exposed to 6 gy gamma radiation in the presence (experimental) or absence (control) of roe to study the qualitative and quantitative alterations ...

Free cholesterol has been considered to be a critical risk factor of nonalcoholic fatty liver disease (NAFLD). It remains unknown whether dietary intake condensed tannins (CTs) have distinguishable effects alleviate damage caused by high diet. Male C57BL/6 mice were fed diet for 6 weeks, and given CTs treatment at dosage 200 mg/(kg·bw·day) the same time. The results indicated that compared with...

1. The synthesis of long-chain fatty acids de novo was measured in the liver and in regions of adipose tissue in intact normal and genetically obses mice throughout the daily 24h cycle. 2. The total rate of synthesis, as measured by the rate of incorporation of 3H from 3H2O into fatty acid, was highest during the dark period, in liver and adipose tissue of lean or obese mice. 3. The rate of inc...

Objective(s): This study aimed to investigate the glucose and lipid metabolism improving effect of the total flavonoids from Selaginella tamariscina (Beauv.) Spring (TFST) on db/db mice, and to study its mechanism of action.Materials and Methods: The db/db mice were divided into 5 groups: the normal group (NC), the diabetic group (DM), t...