Osteosarcoma (OS) is the most prevalent malignant tumor among cases of Rothmund-Thomson syndrome (RTS) with germline mutations of the RECQL4 gene, a member of the RecQ helicase family. We investigated the involvement of the RECQL4 gene in the development of OS unrelated to RTS. RECQL4 mRNA was detected in 9 of 9 OS cell lines by Northern blotting and 26 of 26 OS tumors by RT-PCR. Direct sequenc...

purpose: to report and review a rare variant of duane's syndrome named synergistic divergence and its surgical results. patient and findings: a 16-year-old girl presented with left face turn and reduced vision in both eyes. best corrected vision was od: 3/10 and os: 10/10. there was severe adduction deficiency of the re with simultaneous abduction of the re in left gaze. she had xt= 35 in ...

BACKGROUND In terms of overall survival (OS), limited data are available for the very long-term outcomes of children treated for optic pathway glioma (OPG) with up-front chemotherapy. Therefore, we undertook this study with the aim of clarifying long-term OS and causes of death in these patients. METHODS We initiated and analyzed a historical cohort study of 180 children with OPG treated in F...

Oxidative stress (OS), which has been implicated in pathogenesis of many acute and chronic diseases, plays an important role in diverse neurological disorders including depression and anxiety. OS is caused by a large amount of reactive oxygen species or impaired enzymatic or non-enzymatic defense against it. OS has been suggested to contribute to etiology of mentioned disorders. This review int...

The Hirntumorstudien (HIT)-LGG-1996 protocol offered a comprehensive treatment strategy for pediatric patients with low-grade glioma (LGG), ie, observation, surgery, adjuvant radiotherapy, and chemotherapy to defer the start of irradiation in young children. In this current study, we sought to determine clinical factors for progression and survival. Between October 1, 1996 and March 31, 2004, 1...

oxidative stress (os), which has been implicated in pathogenesis of many acute and chronic diseases, plays an important role in diverse neurological disorders including depression and anxiety. os is caused by a large amount of reactive oxygen species or impaired enzymatic or non-enzymatic defense against it. os has been suggested to contribute to etiology of mentioned disorders. this review int...

Background: Triple negative breast cancer (TNBC) is reported to be associated with a high risk of recurrence, poor overall survival (OS), and disease-free survival (DFS) rates. This study evaluated the clincopathological features and survival of non-metastatic TNBC women in the capital of Iran compared with other areas of the world. Methods: In a retrospective study, 119 women with TNBC based ...

     Osteosarcoma (OS) is a malignant tumor that induces formation of osteoid or immature bone and rarely occurs in maxilla. Maxillofacial OSs are reported to occur in the third to fifth decades that is 1-2 decades later than the mean age for OS of long bones. The present case is a 62-year-old man with facial asymmetry and pain in his left upper jaw. Intraoral examination showed a bony hard, te...