BACKGROUND To determine the expression of bone morphogenetic protein-2 (BMP-2) and its receptors BMPRIA, BMPRIB, and BMPRII in epithelial ovarian cancer (EOC) and to analyze their influence on the prognosis of ovarian cancer patients. METHODS Semi-quantitative RT-PCR and western blot were applied to detect the expression of BMP-2 and its receptors BMPRIA, BMPRIB, and BMPRII in EOC, benign ova...

Background Fertility preservation is an important part of scientific study in the field of reproductive medicine. Ovarian cryopreservation and in vitro follicles culture provide option for fertility conservation in older women or cancer patients. Basic fibroblast growth factor (bFGF) or FGF-2, is member of fibroblast growth factors family which play critical roles in cell migration proliferatio...

BACKGROUND Ovarian tissue cryopreservation is an emerging technique, also addressed to very young cancer patients, for whom it is not possible to perform an ovarian stimulation for oocytes freezing, before gonadotoxic treatment. In this cases, ovarian tissue must be cryopreserved for a long period of time and it is very important to know if it maintains fertility function after a long period of...

OBJECTIVE Comparison of time intervals from diagnosis to chemotherapy between patients opting for embryo cryopreservation or ovarian tissue cryopreservation. STUDY DESIGN Retrospective analysis. SETTING University hospital in the Netherlands. PATIENTS AND METHODS Thirty-five female patients undergoing fertility preservation procedures before treatment with chemotherapy for cancer. Embryo ...

Mature cystic teratoma is the most common benign neoplasm of the ovary, accounting for 27-44% of all ovarian tumors and up to 58% of benign ovarian tumors [1], and is composed of mature-appearing derivatives of two or three embryonal layers [2]. Ectodermal derivatives are observed in almost all mature teratomas [2]. Organized mature neural tissue is a common component. Glial tissue is the most ...

to the editor: Premenopausal women who undergo high-dose chemotherapy have a very high risk of ovarian failure. 1 Cryopreservation of ovarian tissue with subsequent autotransplantation has effectively preserved fertility in an animal model, 2 but its efficacy in humans has been uncertain. Eggs that were aspirated from cryopreserved ovarian tissue transplanted in heterotopic sites did not result...

STUDY QUESTION Do the benefits of ovarian tissue cryopreservation outweigh the risks for patients seeking to preserve fertility before gonadotoxic treatment in various indications? SUMMARY ANSWER In >90% of the patients undergoing cryopreservation of ovarian tissue, oncological treatment was associated with a reduced ovarian reserve and in 30% of patients, premature ovarian failure (POF) occu...

primary ovarian carcinoid tumors of the ovary are rare and represent less than 0.1% of ovarian malignancy. one of its subtypes is the strumal carcinoid in which the thyroid tissue is seen in intimate association with carcinoid tumor. we here report a 47-year-old woman with strumal carcinoid of the right ovary presented with cessation of menstrual periods in the past 3 months and was referred du...