Objective(s):Recently cell therapy is a promising therapeutic modality for many types of disease including acute kidney injury (AKI). Due to the unique biological properties, mesenchymal stem cells (MSCs) are attractive cells in this regard. This study aims to transplant MSCs equipped with nuclear factor E2-related factor 2 (Nrf2) in rat experimental models of acute kidney and evaluate regenera...

INTRODUCTION Mechanical ventilation (MV) is commonly regarded as a risk factor for acute kidney injury (AKI) in the critically ill. We investigated the strength of this association and whether settings of tidal volume (Vt) and positive end-expiratory pressure (PEEP) affect the risk for AKI. METHODS We performed a systematic review and meta-analysis using studies found by searching MEDLINE, EM...

introduction: acute kidney injury (aki) is a common postoperative complication of cardiac surgery, which is associated with an increased risk of morbidity and mortality. this study investigated the frequency of postoperative aki in low risk adult patients undergoing off-pump coronary artery bypass grafting (cabg).materials & methods: all consecutive adult patients of american society of anesthe...

Acute Kidney Injury (AKI) occurs if the kidneys suddenly lose their ability to remove waste products. When the kidneys lose their ability to filter, dangerous levels of waste products can accumulate, which can upset the chemical composition of the blood and urine. Chemotherapy is one of the methods used to treat or temporarily reduce cancer by using certain medications. The main task of this tr...

INTRODUCTION Acute kidney injury (AKI) is a common clinical problem associated with adverse outcomes. This study identifies the incidence of AKI in two UK district general hospitals' without on-site renal services and assesses AKI management and level of nephrologist input. METHODS The AKIN classification was used to identify 1020 AKI patients over 6 months. Data were collated on patient demo...

Poly (ADP-ribose) polymerases (PARPs) are crucial in repairing DNA after a damaging event. However, several studies indicate that more extensive disruption causes overactivity of PARP and can ultimately lead to cellular necrosis particularly the setting ischemia- related or sepsis-related acute kidney injury (AKI). Though anti-cancer effects inhibitors (PARPis) well known, especially cases Brea...

BACKGROUND Acute kidney injury (AKI) after coronary artery bypass grafting (CABG) is associated with significant morbidity and mortality. Controversy exists regarding whether an off-pump technique can reduce post-CABG renal injury. STUDY DESIGN Systematic review and meta-analysis. SETTING & POPULATION Adult patients undergoing CABG. SELECTION CRITERIA FOR STUDIES MEDLINE, EMBASE, Cochrane...