Background and objectives: Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inhibition results in an increase in apoptosis. It has been demonstrated that NF-κB subunit p65 phosphorylation at the IκB kinase phosphorylation site serine 536 (Ser536) is essential for the NF-κB nuclear translocation and activation. Therefore, NF-κB can be downregulated by suppressing its phosph...

Bone is formed through the processes of endochondral and intramembranous ossification. In endochondral ossification primary mesenchymal cells differentiate to chondrocytes and then are progressively substituted by bone, while in intramembranous ossification mesenchymal stem cells (MSCs) differentiate directly into osteoblasts to form bone. The steps of osteogenic proliferation, differentiation,...

background no study from india has examined pathways to care in alcohol using population systematically. objectives the present study aimed to understand the pathways to care among alcohol-dependent individuals seeking help at a tertiary care center. patients and methods it was a cross-sectional, observational study. a total of 58 subjects diagnosed with alcohol- dependence syndrome as per dsm-...

I mmune response in the arthropod vector to virus infection is a critical determinant of transmission for arboviruses such as West Nile virus (WNV). The immune response modulates outcomes of infection such as viral load, incubation period required for transmission, and viral pathogenesis in the vector (1, 2). As insects appear to lack an adaptive immune response characteristic of vertebrates, t...

Thyroid cancer is a frequent endocrine related malignancy with continuous increasing incidence. There has been moving development in understanding its molecular pathogenesis recently mainly through the explanation of the original role of several key signaling pathways and related molecular distributors. Central to these mechanisms are the genetic and epigenetic alterations in these pathways, su...

Dear editor: We would like to present a modified method for cerebrospinal fluid collection in anesthetized rat. This method is easy and applicable in many laboratories interested by research on cellular and molecular effects of CSF on different pathways.