The reaction of acid hydrazides (1a-c) with 2-chloro-1-(4-chlorophenyl)ethanone (2a) or 2-bromo-1-(4-bromophenyl)ethanone (2b) afforded bis-hydrazones 6a-d, while the reaction of la-c with 2-oxo-N-arylpropanehydrazonoyl chlorides (3a,b) furnished N-(aryl)propanehydrazonoyl chlorides 8a-c. The reaction of the latter chlorides with sodium benzenesulfinate furnished sulfones 11a-c. On the other ha...

This paper presents evidence that zinc filtrates (particularly the Hagedorn-Jensen (1923) filtrates) of urine (after treatment with hydrogen peroxide), whole blood, plasma, or serum are suitable for the accurate determination of chlorides with dichlorofluorescein as an indicator. The precision of this method for urine chlorides has been shown by comparison with established procedures such as th...

A convenient route for the preparation of C2-substituted imidazolium ionic liquids is reported. This method involves the alkylation of N-heterocyclic carbenes, which are readily generated from the C2-unsubstituted imidazolium ionic liquids. It works well for non-functionalized alkyl chlorides, and less well for alkyl bromides and iodides, likely due to competing elimination reactions. The resul...

Alkylidenepyrrolidines 1, 21, 24 and 26 undergo reactions with nitrile oxides and nitrilimines or their precursors to give a range of novel heterocyclic compounds. With alkylidenepyrrolidine ester 1, nitrolic acids give products in which the liberated nitrous acid reacts with the alkylidenepyrrolidine, followed by two cycloadditions to give adducts 3. In contrast, hydroximoyl chlorides give iso...

The synthesis of amide C N bonds through nucleophilic acyl substitutions constitutes one of the most fundamental transformations in chemical synthesis. Recently, the Staudingertype ligation of carboxylic acid derivatives (e.g., acid chlorides, anhydrides, acyl selenides, and thioesters) and azides has become a preeminent strategy for amide C N bond construction (Scheme 1a). However, the generat...

Abstract Aliphatic esters are essential constituents of biologically active compounds and versatile chemical intermediates for the synthesis drugs. However, their preparation from readily available olefins remains challenging. Here, we report a strategy to access aliphatic through photocatalyzed alkoxycarbonylation reaction. Alkyloxalyl chlorides, generated in situ corresponding alcohols oxalyl...

This work investigates the potential of magnetic Fe3O4 nanoparticles as an adsorbent for separation and preconcentration of trace amounts of mefenamic acid in aquatic and biological samples, prior to spectrophotometric determination. The magnetic iron oxide nanoparticles (MIONs) were synthesized by mixing of ferrous and ferric chlorides. The possible parameters affecting the enrichment were opt...

Stable enols were synthesized from the reaction of (1Z,3Z)-1,4-dilithio-1,3-dienes with acid chlorides and structurally characterized by single-crystal X-ray analysis. These stable enols were formed by a novel de-aromatization/Michael addition/re-aromatization domino process.