Procaine amide was given intravenously to three patients with transient ventricular fibrillation during established auriculoventricular dissociation at a time when they were free from symptoms as well as during the attacks. It was determined that this drug has a transitory slowing effect upon the auricles. It depresses rhythmicity in the auriculoventricular node, prolongs the refractory period ...

BACKGROUND Perineuriomas have been defined as tumorous lesions of the peripheral nerves which derive from perineurial cell proliferation and may be associated with abnormalities on chromosome 22. CASE PRESENTATION Three years after a painful cubital vein procaine injection, a 33 year-old man developed a median nerve lesion, initially diagnosed as carpal tunnel syndrome. Symptoms progressed de...

Sensitivity of the tonic stretch reflex (TSR) of biceps brachii in normal man was measured at different levels of voluntary contraction before and after gamma efferent nerve fibres were selectively blocked by infiltration of dilute procaine. The procaine infiltration reduced TSR sensitivity to one half of its control value. It had no effect, however, on the slope of the relation between TSR gai...

OF all the methods of delaying the absorption of intramuscular penicillin, combination with procaine is at present foremost (Florey 1952). Procaine penicillin is most effective when the particles are smaller than 5 µ and are suspended in a peanut-oil medium with 2% (w/v) aluminium monostearate (Thomas et al. 1948). Emery et al. (1949) showed that in children a serum-penicillin level above...

INTERRUPTION of ventricular fibrillation with the use of drugs has generally been found to be unsuccessful. Previous work on local anesthetic agents suggested that such compounds could terminate ventricular fibrillation; however, Stearns, Maison and Stutzman reported little success with the use of procaine. Wegria and co-workers' conclude in their studies that procaine may stop fibrillation; ho...

Procaine amidle, a inems synthetic analogue of procaine, has marked antiarlivtluiic alctivity aial is relatively stable in the bo(ld-. It is; effective when administered orallor intra enously, an(l has fe\ toxic effects in therapeutic (loses. The (rug has been used successfully in tI e suppression of yenitriculai p)remiature contractions aind in the interruption of ventricular tachveardia. Some...

BACKGROUND Parenteral antibiotic therapy for young infants (aged 0-59 days) with suspected sepsis is sometimes not available or feasible in countries with high neonatal mortality. Outpatient treatment could save lives in such settings. We aimed to assess the equivalence of two simplified antibiotic regimens, comprising fewer injections and oral rather than parenteral administration, compared wi...

The vascular effects and duration of action of two ester-linked local anaesthetics, procaine and amethocaine, and four amide-linked local anaesthetics, cinchocaine, lignocaine, mepivacaine and prilocaine, were investigated in 10 volunteers by intradermal injection using a double-blind technique. Procaine and amethocaine produced marked vasodilatation; weal formation was observed at 80% of the a...