Objective: Cervical cancer is the second most common type of cancer among women, worldwide; and for treatment of this type of cancer radiotherapy is commonly used. Ferula gummosa Boiss(“Barije” in Persian, from the family Apiaceae), (F. gummosa), is an extremely precious medicinal plant which naturally grows throughout the Mediterranean and Central Asia and is a native plant in Iran. The presen...

Background: The aim of this study was to estimate the cancer risks and mortalities of different types induced by routine examinations of digital radiography for one year in Mazandaran province, Iran. Materials and methods: Radiation parameters and calculated entrance skin dose (ESD) values of 13 digital radiographic examinations were collected from 2340 patients at 18 high-patient-load radiogra...

Systematic bio- and databanks are key prerequisites for modern radiation research to investigate response mechanisms in the context of genetic, environmental lifestyle-associated factors. This report presents current status German Uranium Miners’ Biobank. In 2008, databank was established at Federal Office Radiation Protection, sampling biological materials from former uranium miners with witho...

Background: Computed tomography angiography (CTA) scan is a suitable imaging technique to evaluate the blood vessels. However, one major disadvantage is the potential risk of cancer related to ionizing radiation exposure during the procedures. The aim of this investigation was to estimate the risk of exposure induced cancer death (REID) values for some common computed tomography angiography (CT...

background: radiation-induced discomfort is frequently observed during pelvic radiotherapy. this study was performed to determine the effect of a green tea tablet to reduce the incidence of radiation-induced diarrhea and vomiting in patients with abdomen and pelvic malignancy. materials and methods: this randomized controlled clinical trial recruited 42 patients with abdomen and pelvic malignan...

background: bladder cancer (bc) is the most common genitourinary cancer in iranians with an unclear etiopathogenesis. long stress induced non-coding transcript 5 is a member of the 12-member family of long non-coding rnas, which is abundantly expressed in higher proliferative cells, as well as the cell vulnerable to cellular stress in response to chemical carcinogens. as variations in long non-...

BACKGROUND Nimotuzumab is a humanized IgG1 monoclonal antibody specifically targeting EGFR. In this study, we aimed to investigate the molecular mechanisms of nimotuzumab in its effects of enhancing cancer cell radiosensitivity. PRINCIPAL FINDING Lung cancer A549 cells and breast cancer MCF-7 cells were pretreated with or without nimotuzumab for 24 h before radiation to perform the clonogenic...

Despite the fact that ionizing radiation (IR) is widely used as a standard treatment for breast cancer, much evidence suggests that IR paradoxically promotes cancer malignancy. However, the molecular mechanisms underlying radiation-induced cancer progression remain obscure. Here, we report that irradiation activates SRC signaling among SRC family kinase proteins, thereby promoting malignant phe...

Radiation-induced damage is a complex network of interlinked signaling pathways, which may result in apoptosis, cell cycle arrest, DNA repair, and cancer. The development of thyroid cancer in response to radiation, from nuclear catastrophes to chemotherapy, has long been an object of study. A basic overview of the ionizing and non-ionizing radiation effects of the sensitivity of the thyroid gla...