this study was performed to assess the clopidogrel activity in inhibition of platelet aggregation in suspected angina patients on a daily dosag of 75 mg of clopidogrel for at least 7 days. this clinical trial was conducted in the outpatients department of cardiology, post graduate medical institute, lady reading hospital, peshawar from 15th october 2007 to 20th december 2007. we included 105 su...

Introduction: Profilin1 (PFN1) is a ubiquitously expressed protein known for its function as a regulator of actin polymerization and dynamics. A recent discovery linked mutant PFN1 to Amyotrophic Lateral Sclerosis (ALS), which is a fatal and progressive motor neuron disease. We have also demonstrated that Gly118Val mutation in PFN1 is a cause of ALS, and the formation of aggregates containing m...

In our present investigation, a series of novel 4-methoxy-1,3-benzenediolyl-hydrazones were designed and synthesized, and their ability to inhibit platelet aggregation was evaluated by adenosine diphosphate (ADP) and arachidonic acid (AA). The structures of the synthesized compounds were confirmed by spectral data. Results demonstrated that the activities of all compounds excelled the positive d...

Systematic studies on the vapor-liquid equilibria (VLE) and conductometric properties of aqueous solutions of model surface-active ionic liquid 1-dodecyl-3-methylimidazolium bromide ([C12mim]Br) are performed in the absence and presence of a large series of electrolytes in order to achieve a deeper understanding about the molecular mechanism behind the specific salt effect on the aggregation be...

Working in the Arrovian framework, we search for preference aggregation rules with desirable solidarity properties. In a fixed-population setting, we formulate two versions of the solidarity axiom welfare dominance under preference replacement. Although the stronger proves incompatible with efficiency, the combination of efficiency and our second version leads to an important class of rules whi...

effects of ?-cyclodextrin, ?cd, on refolding of lysozyme was investigated at ph 12 employing isothermal titration calorimetry (itc) at 300k in 30mm tris buffer solution. ?cd was employed as an anti-aggregation agent and the heats obtained for lysozyme+?cd interactions are reported and analyzed in terms of the extended solvation model. it was indicated that there are two sets of identical and no...

electrochemical oxidation of some selected catechol derivatives, using cyclic voltammetry, in the presence of different 2-aryl-1,3-indandiones as nucleophiles, resulted in electrochemical synthesis of new 1,3- indandione derivatives in an undivided cell in good yield and purity. a michael addition mechanism was proposed for the formation of the analogs based on the reaction conditions which wer...

The development of cloud computing and distributed technologies has shifted log management operations to an aggregated form. Diverse information devices as well systems perform data collection status analysis through a unified aggregation system. However, with the increasingly diverse business forms, threats confronted by are also mounting, among which leakage, tampering, loss, security vulnera...