just like any other process, vaccine manufacturing procedures are defined as a series of interrelated functions and activities using a variety of specified actions and equipment designed to produce a defined product. to assure the reproducibility and consistency of such processes, they must be carried out using validated equipment and under the established procedures that meet all the acceptanc...

evaluation of functional disability using proper instruments, like health assessment questionnaire (haq) in patients with rheumatoid arthritis (ra), is necessary not only for quality of life assessment, but also as a useful marker for disease activity. haq has been translated into many languages. to validate the persian version of stanford haq. persian version of the haq (pe-haq) with culturall...

Safety validation of changes to an individual organization’s local ATM system has become common practice in Europe. However, the SESAR program is planning changes in air traffic operations in Europe that go much further than changes to a local ATM system. This paper identifies the issues on which safety validation approaches need extensions, in order to move from safety validation of changes to...

FACES IV was developed to tap the full continuum of the cohesion and flexibility dimensions from the Circumplex Model of Marital and Family Systems. Six scales were developed, with two balanced scales and four unbalanced scales designed to tap low & high cohesion (disengaged and enmeshed) and flexibility (rigid and chaotic). This study provides initial evidence the six scales in FACES IV are re...

DNA evidence can pose interpretation challenges, particularly with low-level or mixed samples. It would be desirable to make full use of the quantitative data, consider every genotype possibility, and objectively produce accurate and reproducible DNA match results. Probabilistic genotype computing is designed to achieve these goals. This validation study assessed TrueAllele(®) probabilistic com...

Deep learning methods have recently made notable advances in the tasks of classification and representation learning. These tasks are important for brain imaging and neuroscience discovery, making the methods attractive for porting to a neuroimager's toolbox. Success of these methods is, in part, explained by the flexibility of deep learning models. However, this flexibility makes the process o...

Picky eating is prevalent in childhood and is associated with negative health outcomes. Therefore early detection of pickiness is pertinent. Because no psychometric measure of picky/fussy eating has been validated, we aimed to examine the screening efficiency of the 6-item 'Food Fussiness' (FF) scale from the Children's Eating Behavior Questionnaire using structured psychiatric interviews (the ...

BACKGROUND The aim of this study was to assess validation evidence for a sedation scale for dogs. We hypothesized that the chosen sedation scale would be unreliable when used by different raters and show poor discrimination between sedation protocols. A sedation scale (range 0-21) was used to score 62 dogs scheduled to receive sedation at two veterinary clinics in a prospective trial. Scores re...

Developmental delay is a common diagnosis given in clinical practice to young children whose developmental milestones fail to be met in a typical age-expected manner. Research on early delays in speech and motor milestones remains unclear regarding long-term developmental outcomes. The purpose of this study was to cross-validate and further investigate subsequent diagnoses (more than 4 years po...