Cyclophosphamide (CP) is one of the anti-neoplastic drugs. Despite its numerous clinical applications, it has devastating effects on the testicles and declines the sperm quality in treated patients. This study was aimed to investigate the protective effect of crocin in improving the toxicity induced by CP in reproductive system. In this study, 24 male adult mice (6 to 8 weeks) were randomly div...

Density functional theory (DFT) calculations were performed on tripeptide arginyl-glycyl-aspartic acid (RGD) as an efficient drug carrier to deliver the commercially famous cyclophosphamide (CP) anticancer drug within ethanol solution. The most negative binding energy (-5.22 kcal/mol) was measured for the CP-RGD-7 created through the H-bond interaction between the P=O (phosphoryl) oxygen atom o...

The place of Neandertals in modern human emergence has been a subject of debate since the first recognized Neandertal skeleton was discovered in 1856. This paper presents an overview of morphological, archaeological, and genetic evidence commonly used in discussions of Neandertals and their evolutionary significance. A brief historical sketch of the argument provides insight into the changing v...

ThehumanpregnaneX receptor (hPXR) is a xenobiotic-sensing nuclear receptor that transcriptionally regulates drug metabolism–related genes. The aim of the present study was to elucidate the mechanism by which hPXR is regulated through threonine-408. A phosphomimetic mutationat threonine-408 (T408D) reduced the transcriptional activity of hPXR and its protein stability in HepG2 and SW480 cells in...

(This article does not have an abstract.) Toni Dávila George Foster Daniel Oyon “Accounting and control, entrepreneurship and innovation: Venturing into new research opportunities”, European Accounting Review, Vol. 18, No 2, June 2009, pages 281–311. Abstract: The relevance of accounting and control to entrepreneurship and innovation has become more salient over the last few years. The traditio...