نتایج جستجو برای: flowcytometry
تعداد نتایج: 557 فیلتر نتایج به سال:
Abstract Hypothesis The implementation of the proposal from European Chemical Agency (ECHA) to restrict use nanoplastics (NP) and microplastics (MP) in consumer products will require reliable methods perform size mass-based concentration measurements. Analytical challenges arise at nanometre micrometre interface, e.g., 800 nm–10 µm, where techniques applicable scale reach their upper limit appl...
Background and purpose: Üsing immunotyping in classifying leukemia is growing increasingly. This method provides useful information about proper classifying of leukemia, the prognosis and treatment of this disease. This study is conducted to determine frequency percentage of ÇD markers in patients suffering from acute leukemia who had referred to Ïmam Khomeini Hospital in Ürmia for one year. ...
Background and Aim: Chronic myelogenous leukemia is characterized by Philadelphia (Ph) chromosome, the presence of BCR-ABL fusion gene and constitutive activation of the ABL1 tyrosine kinase. Despite an excellent result of target therapy by imatinib, some patients develop resistance to imatinib. In this study Efficacy of HESA-A on proliferation and apoptosis of K562 cell line was assessed. Mat...
Background: Safe and effective gene therapy is considered as one of the therapeutic goals in many diseases. Due to the important role of stem cells in cell therapy, this study aimed to produce human adipose-derived mesenchymal stem cells (hASCs) using the miR-34a overexpression. Materials and methods: The hsa-mir-34a precursor sequence was cloned into the PCDH lentiviral vector. The recombinant...
Abstract Background B lymphocyte activating factor (BAFF) is a growth regulating lymphocytes survival and maturation. Serum BAFF levels were elevated in patients affected with autoimmune thyroid diseases (AITD), including Graves’ disease (GD) Hashimoto’s thyroiditis (HT). The aim of this study to explore the association expression its receptors AITD. Methods Fifty-two GD patients, 39 (HT) 23 he...
the genus of aegilops a wild and weedy relative of bread wheats, has wide distribution in middle east and west asia, these areas include major parts of iran. the species in this genus have a great role in hexaploid wheat evolution and they are donor of d and b genome, directly and indirectly. to identify some iranian aegilops accessions, one handred and three accessions from eight species from ...
Background & Aims: Nowadays, by advent of hybridoma technology in monoclonal antibodies production various cell markers could be evaluated in malignant and non-malignant cells. CD20, non-glycosylated phosphoprotein is as an ideal marker in leukemia and B-cell lymphoma diagnosis which is expressed on more than 95% of normal and neoplastic B-cells except for early B-cells and mature plasma. Th...
Background: Lymphocyte subsets enumeration is considered prominent in the management of primary and acquired immunodeficiency disorders. Because of local variations due to race, age, gender, and environmental conditions on lymphocyte subsets, and to improve the accuracy of interpretation of laboratory findings, reference intervals must be determined in every population. Objective: To establish ...
Abstract OBJECTIVE Medulloblastoma represents one of the most common brain tumors in children. In this study, we identified by BH3 profiling that ONC201/TIC10 sensitizes for Bcl-xL/Bcl-2 inhibition medulloblastoma and performed a preclinical testing combined treatment with inhibitor ABT-263. METHODS was to examine ONC201/TIC10-mediated dependencies on anti-apoptotic Bcl-2 family proteins. The c...
Abstract The highly immunosuppressive tumor microenvironment (TME) stimulates cancer cells resistance to immunotherapy. We have previously shown that a live-attenuated Brucella melitensisΔ vjbR(BmΔ vjbR) bacterial strain, breaks cell immunotherapy by remodeling the TME and facilitating infiltration of cytotoxic CD8 +T (CTLs) into tumor. As result, there was shrinkage size significant improvemen...
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