Offspring of parents with a history of cardiovascular disease (CVD) inherit a similar genetic profile and share diet and lifestyle behaviors. This study aimed to evaluate the feasibility of recruiting families at risk of CVD to a dietary prevention program, determine the changes in diet achieved, and program acceptability. Families were recruited into a pilot parallel group randomized controlle...

Common fragile sites (CFSs) represent large, highly unstable regions of the human genome. CFS sequences are sensitive to perturbation of replication; however, the molecular basis for the instability at CFSs is poorly understood. We hypothesized that a unique epigenetic pattern may underlie the unusual sensitivity of CFSs to replication interference. To examine this hypothesis, we analyzed chrom...

Understanding the fundamental dynamics of epigenome variation during normal aging is critical for elucidating key epigenetic alterations that affect development, cell differentiation and diseases. Advances in the field of aging and DNA methylation strongly support the aging epigenetic drift model. Although this model aligns with previous studies, the role of other epigenetic marks, such as hist...

hymenolepis nana is a common parasite of rodents as well as human intestine. this parasite has beenreported from all over the world, including iran. the infection rate has been reported up to 40% in someareas. the infection has various clinical manifestations. the parasite could establish severe hyperinfection inpatients with immune deficiency. regarding the rodents as hosts of the parasite, th...

backgrund: imprinted genes are a unique subset of few genes, which have been differentially methylated region (dmr) in a parental origin-dependent manner during gametogenesis, and these genes are highly protected during pre-implantation epigenetic reprogramming. several studies heve shown that the particular vulnerability of imprinting genes during suboptimal pre- and peri-conception microenvir...