Narrow-band (312 nm) ultraviolet B light (UVB) is a new form of therapy for psoriasis, but its mechanism of action is unknown. In a bilateral comparison clinical study, daily exposure of psoriatic plaques to broad-band UVB (290-320 nm) or 312-nm UVB depleted T cells from the epidermis and dermis of psoriatic lesions. However, 312-nm UVB was significantly more depleting in both tissue compartmen...

Abstract Introduction : Psoriasis is a chronic, common immune inflammatory condition of the skin, affecting 2-3% population, with regional variability. Classically, psoriasis presents as one following types: plaque, guttate, inverse, pustular or erythrodermic psoriasis. Typically, patient will present several symmetric psoriatic plaques on typical areas body, leading clinician towards diagnosis...

In order to study the prevalence of psoriatic arthritis in Imam Reza Hospital and determine the effects of factors like age, sex, familial history, type of skin involvement, nail involvement and duration of disease on psoriatic arthritis, 300 psoriatic patients over a period of 4 years were admitted and examined in the Department of Dermatology and Rheumatology in Imam Reza Teaching Hospita...

SUMMARY Since Farvardin 1366 to Esfand 1367 (March 1987 to March 1989) more than 60 psoriatic patients hospitalized in Loghman Hakim Medical Center were evaluated for age, sex, place of birth, morphology of psoriatic lesion, . duration of the disease, association with arthropathy, sensitivity to light, nail involvement, history ofinkction, emotional stress and family history, also scrum calciu...

In addition to being T lymphocyte-driven, psoriasis may be due in part to abnormal integrin expression. Normal-appearing (uninvolved) skin from psoriatic patients was examined to determine whether altered fibronectin or its receptor expression is detectable before development of psoriatic lesions. In contrast to skin from normal subjects, we detect by immunofluorescence the abnormal presence of...

Psoriatic skin differs distinctly from normal skin by its thickened epidermis. Most gene expression comparisons utilize full-thickness biopsies, with substantial amount of dermis. We assayed the transcriptomes of normal, lesional, and non-lesional psoriatic epidermis, sampled as split-thickness skin grafts, with 5'-end RNA sequencing. We found that psoriatic epidermis contains more mRNA per tot...

Topical corticosteroids, alone or in combination with calcipotriol, a topical vitamin D analog, have proved effective treating mild to moderate psoriasis. like clobetasol propionate, vasoconstrictor effect on the peripheral dermal vessels, and this explains skin atrophy psoriatic patients applying corticosteroids regularly for long periods. However, new treatment psoriasis has been developed pa...

Psoriasis is a chronic inflammatory dermatosis characterized by hyperproliferative keratinocytes (KC). The skin lesions are infiltrated by T cells, which secrete gamma interferon (γ-IFN) and are believed to be necessary to maintain the psoriatic phenotype. In normal KC, γ-IFN is a potent inhibitor of proliferation, but proliferation of KC persists in psoriatic plaques despite the presence of γ-...