Matveyenko AV, Veldhuis JD, Butler PC. Adaptations in pulsatile insulin secretion, hepatic insulin clearance, and -cell mass to age-related insulin resistance in rats. Am J Physiol Endocrinol Metab 295: E832–E841, 2008. First published July 29, 2008; doi:10.1152/ajpendo.90451.2008.—In health insulin is secreted in discrete insulin secretory bursts from pancreatic -cells, collectively referred t...

Metformin has been found to reduce elevated gonadotropin levels. Hashimoto’s thyroiditis is the most common thyroid disorder in iodine-sufficient areas, and it often develops postmenopausal women. The aim of this study was investigate whether autoimmune determines impact metformin on gonadotrope secretory function. Two matched groups women were studied: 35 with euthyroid (group A) without disor...

BACKGROUND A strong but presently unexplained inverse association between blood pressure and insulin sensitivity has been reported. Microvascular vasodilator capacity may be a common antecedent linking insulin sensitivity to blood pressure. To test this hypothesis, we studied 18 normotensive and glucose-tolerant subjects showing a wide range in insulin sensitivity as assessed with the hyperinsu...

INTRODUCTION Cytokines produced by adipose tissue, including adiponectin, have been associated with metabolic abnormalities. The purpose of this study was to examine the relationship of insulin sensitivity measured by euglycemic hyperinsulinemic insulin clamp with plasma adiponectin and other adipokines in young adult African Americans. METHODS Participants were healthy African Americans. Ant...

Objective(s): Visfatin and vaspin are secreted by adipose tissue and play key roles in glucose homeostasis and subsequently are potential targets for diabetes treatment. Resveratrol (RVS) corrects insulin secretion and improves insulin sensitivity. We investigated the RVS effects on serum antioxidants, insulin and glucose levels, also visfatin and vaspin genes expression in adipose tissue of st...