Lipid-based nanocarriers have been extensively investigated for drug delivery due to their advantages including biodegradability, biocompatibility, nontoxicity, and nonimmunogenicity. However, the shortcomings of traditional lipid-based such as insufficient targeting, capture by reticuloendothelial system, fast elimination limit efficiency therapeutic efficacy. Therefore, a series multifunction...

Ionizable Lipid Nanoparticles nanoparticle (LNP) systems are currently the leading nonviral delivery for enabling clinical potential of mRNA drugs. lipid is critical component nanoparticles. In article 2202590 by Gengshen Song, Jing Yang, Shengqi Wang, and co-workers, a novel ionizable YK009 designed developed LNP formulation. The YK009-LNP shows high efficacy good safety. An vaccine against SA...

Lipid-coated metal nanoparticles are developed here as a mimic of low-density lipoprotein (LDL) particles and used to study C-reactive protein (CRP) binding to highly curved lipid membranes. A 12 nm shift in the localized surface plasmon resonance (LSPR) was observed when CRP was added to the lipid-coated gold nanoparticles. Transmission electron microscopy (TEM) revealed that CRP induced a str...

Parietaria pollen is one of the major causes of allergic reaction in southern Europe, affecting about 30% of all allergic patients in this area. Specific immunotherapy is the only treatment able to modify the natural outcome of the disease by restoring a normal immunity against allergens. The preparation of allergen-solid lipid nanoparticles as delivery vehicles for therapeutic proteins, P. jud...

During the past decade, the number of studies describing nanostructured lipid carriers (NLCs)-based formulations has been dramatically increased. The raise in NLC exploitation is essentially due to defeated barriers within the technological process of lipid-based nanoparticles' formulation and increased knowledge of the underlying mechanisms of transport of NLCs via different routes of administ...

Solid lipid nanoparticles (SLNs) are a well-tolerated lipid carrier system due to the employment of a physiological and/or biodegradable lipid matrix. Physicochemical properties such as particle size, polydispersity index (PI) and zeta potential are SLN quality response parameters. Increased particle size is a good indicator of in-vitro instability. This work focuses on the importance of select...